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LOC114515524 olfactory receptor enhancer Crete [ Mus musculus (house mouse) ]

Gene ID: 114515524, updated on 9-Aug-2024

Summary

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Gene symbol
LOC114515524
Gene description
olfactory receptor enhancer Crete
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366822
Summary
This genomic region represents one of several intergenic enhancers, known as Greek islands, which aggregate to form an interchromosomal hub that enables expression of a single olfactory receptor (OR) gene in olfactory sensory neurons. While all of the other OR gene clusters are sequestered in a large heterochromatic domain, this multi-enhancer interaction network evades heterochromatic silencing by associating with the transcription factors Lhx2 (LIM homeobox 2) and Ebf (EBF transcription factor), which bind in a functionally cooperative manner to allow expression of the active OR gene. The Greek island represented in this genomic region, Crete, was validated as a functional enhancer by reporter assays in olfactory sensory neurons of transgenic zebrafish embryos. Additionally, upregulation of the nearby OR gene cluster (Or6b2, Or6b2b, Or6b3, Or9s13, Or9s14, Or9s15, Or9s23 and Or9s27) was observed in olfactory epithelium when an array, which included this enhancer along with the Lipsi, Sfaktiria, H and Rhodes Greek islands, was inserted next to the endogenous Rhodes enhancer. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC114515524 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73925754..73927376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74034928..74036550)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily E member 1F Neighboring gene olfactory receptor family 1 subfamily JRmember 1 Neighboring gene olfactory receptor family 3 subfamily A member 10 Neighboring gene olfactory receptor family 3 subfamily A member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosomes come together to help mice distinguish odours. Spitz F. Nature, 2019 Jan. PMID 30666054
  2. Monoallelic expression of olfactory receptors. Monahan K, et al. Annu Rev Cell Dev Biol, 2015. PMID 26359778, Free PMC Article
  3. How keeping active pays off in the olfactory system. Monahan K, et al. Elife, 2012 Dec 13. PMID 23240088, Free PMC Article
  4. LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice. Monahan K, et al. Nature, 2019 Jan. PMID 30626972, Free PMC Article
  5. Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons. Monahan K, et al. Elife, 2017 Sep 21. PMID 28933695, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • Crete Greek island enhancer
  • regulatory region 366822

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_064615.1 

    Range
    101..1723
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73925754..73927376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials