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STK11IP serine/threonine kinase 11 interacting protein [ Homo sapiens (human) ]

Gene ID: 114790, updated on 2-Nov-2024

Summary

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Official Symbol
STK11IPprovided by HGNC
Official Full Name
serine/threonine kinase 11 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:19184
See related
Ensembl:ENSG00000144589 MIM:607172; AllianceGenome:HGNC:19184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIP1; LKB1IP; STK11IP1
Summary
Enables protein kinase binding activity. Involved in protein localization. Located in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 10.6), spleen (RPKM 4.9) and 24 other tissues See more
Orthologs
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Genomic context

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See STK11IP in Genome Data Viewer
Location:
2q35
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219597857..219616451)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (220082587..220101184)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220462579..220481173)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220441287-220441862 Neighboring gene inhibin subunit alpha Neighboring gene RN7SK pseudogene 213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17156 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220469784-220470983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220472989-220473488 Neighboring gene uncharacterized LOC124908064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220492855-220493557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220493558-220494259 Neighboring gene solute carrier family 4 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220508228-220508999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220509771-220510541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220510542-220511311 Neighboring gene CRISPRi-validated cis-regulatory element chr2.6714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220528008-220528541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220537307-220537807 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:220548733-220549932 Neighboring gene DNAJB6 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. Tian M, et al. J Cell Mol Med, 2021 Mar. PMID 33486894, Free PMC Article
  2. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Conde E, et al. Hum Pathol, 2007 Sep. PMID 17521700
  3. Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1. Morén A, et al. J Biol Chem, 2011 Jan 7. PMID 20974850, Free PMC Article
  4. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
  5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. Nagase T, et al. DNA Res, 2001 Aug 31. PMID 11572484

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
    Title: LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
  2. LKB1 and LIP1 provide negative control of TGFbeta signaling.
    Title: Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
  3. observations provide complete information about the pattern and levels of LKB1 & p-acetyl-CoA carboxylase immunostaining in normal tissues and in lung tumors, and highlight the special relevance of abnormalities of the LKB1 pathway in lung adenocarcinoma
    Title: Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane HDA PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 11-interacting protein
Names
LKB1-interacting protein 1
STK11 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052902.4 → NP_443134.3  serine/threonine-protein kinase 11-interacting protein

    Status: VALIDATED

    Source sequence(s)
    AC009955, BC014114, BC034051, HY001118
    Consensus CDS
    CCDS46521.2
    UniProtKB/Swiss-Prot
    C9JQV3, Q8N1F8, Q8NAW9, Q8WXE4, Q96CN3, Q96PY9
    Related
    ENSP00000389383.1, ENST00000456909.6
    Conserved Domains (4) summary
    COG4886
    Location:101 → 301
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:160 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam15904
    Location:4 → 93
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668 → 719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219597857..219616451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510526.2 → XP_011508828.1  serine/threonine-protein kinase 11-interacting protein isoform X2

    Conserved Domains (6) summary
    cd00116
    Location:110 → 289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 93
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668 → 719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

  2. XM_011510527.4 → XP_011508829.1  serine/threonine-protein kinase 11-interacting protein isoform X3

    Conserved Domains (6) summary
    cd00116
    Location:110 → 289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 93
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668 → 719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

  3. XM_047443102.1 → XP_047299058.1  serine/threonine-protein kinase 11-interacting protein isoform X4

  4. XM_047443104.1 → XP_047299060.1  serine/threonine-protein kinase 11-interacting protein isoform X5

  5. XM_011510529.2 → XP_011508831.1  serine/threonine-protein kinase 11-interacting protein isoform X6

    UniProtKB/TrEMBL
    B4DUE4
    Conserved Domains (5) summary
    cd00116
    Location:110 → 289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 93
    LIP1; LKB1 serine/threonine kinase interacting protein 1

  6. XM_011510528.3 → XP_011508830.1  serine/threonine-protein kinase 11-interacting protein isoform X1

    Conserved Domains (1) summary
    cl19201
    Location:313 → 364
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

RNA

  1. XR_922834.3 RNA Sequence

  2. XR_922835.3 RNA Sequence

    Related
    ENST00000475396.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    220082587..220101184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340334.1 → XP_054196309.1  serine/threonine-protein kinase 11-interacting protein isoform X7

  2. XM_054340335.1 → XP_054196310.1  serine/threonine-protein kinase 11-interacting protein isoform X8

  3. XM_054340336.1 → XP_054196311.1  serine/threonine-protein kinase 11-interacting protein isoform X9

  4. XM_054340337.1 → XP_054196312.1  serine/threonine-protein kinase 11-interacting protein isoform X10

  5. XM_054340339.1 → XP_054196314.1  serine/threonine-protein kinase 11-interacting protein isoform X11

  6. XM_054340338.1 → XP_054196313.1  serine/threonine-protein kinase 11-interacting protein isoform X1

RNA

  1. XR_008486255.1 RNA Sequence

  2. XR_008486256.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1F8.4 GenPept UniProtKB/Swiss-Prot:Q8N1F8

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