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TGM7 transglutaminase 7 [ Homo sapiens (human) ]

Gene ID: 116179, updated on 14-Nov-2024

Summary

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Official Symbol
TGM7provided by HGNC
Official Full Name
transglutaminase 7provided by HGNC
Primary source
HGNC:HGNC:30790
See related
Ensembl:ENSG00000159495 MIM:606776; AllianceGenome:HGNC:30790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGMZ
Summary
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See TGM7 in Genome Data Viewer
Location:
15q15.2-q15.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43276271..43302255, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41083563..41109555, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43568469..43594453, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene transglutaminase 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9311 Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:43589862-43590498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:43622679-43623629 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene N6-Methyl-AMP deaminase Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43647073-43647266 Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6385

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phage-displayed peptide library screening for preferred human substrate peptide sequences for transglutaminase 7. Kuramoto K, et al. Arch Biochem Biophys, 2013 Sep 1. PMID 23876241
  2. HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A. Amendola A, et al. FEBS Lett, 1994 Feb 21. PMID 7906657
  3. Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro. Mariniello L, et al. Eur J Biochem, 1993 Jul 1. PMID 7688299
  4. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. Grenard P, et al. J Biol Chem, 2001 Aug 31. PMID 11390390
  5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Then, using the most efficient peptide, Z3S, we established an in vitro assay system to assess enzymatic activity of TG7.
    Title: Phage-displayed peptide library screening for preferred human substrate peptide sequences for transglutaminase 7.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cyclosporin (CsA) treatment prevents gp120-dependent induction of apoptosis by blocking the activation of Ca(2+)-dependent effector elements such as transglutaminase (TG) proteins PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro; soluble CD4 can block the transglutaminase-catalyzed incorporation of the polyamine spermidine into HIV-1 gp41 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase Z
Names
TG(Z)
TGZ
TGase Z
TGase-7
transglutaminase Z
NP_443187.1
XP_016877392.1
XP_054233236.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052955.3 → NP_443187.1  protein-glutamine gamma-glutamyltransferase Z

    See identical proteins and their annotated locations for NP_443187.1

    Status: VALIDATED

    Source sequence(s)
    AC009852, AF363393, BX112796
    Consensus CDS
    CCDS32213.1
    UniProtKB/Swiss-Prot
    Q96PF1
    Related
    ENSP00000389466.2, ENST00000452443.3
    Conserved Domains (4) summary
    smart00460
    Location:272 → 364
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:275 → 370
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:8 → 122
    Transglut_N; Transglutaminase family
    pfam00927
    Location:608 → 705
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43276271..43302255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021903.1 → XP_016877392.1  protein-glutamine gamma-glutamyltransferase Z isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41083563..41109555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377261.1 → XP_054233236.1  protein-glutamine gamma-glutamyltransferase Z isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PF1.1 GenPept UniProtKB/Swiss-Prot:Q96PF1

Gene LinkOut

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