OLIG1 oligodendrocyte transcription factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OLIG1provided by HGNC
Official Full Name: oligodendrocyte transcription factor 1provided by HGNC
Primary source: HGNC:HGNC:16983
See related: Ensembl:ENSG00000184221 MIM:606385; AllianceGenome:HGNC:16983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BHLHB6; BHLHE21
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within neuron fate commitment. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 21q22.11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (33070141..33072413)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (31438351..31440623)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (34442447..34444719)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin.
Title: Olig1 is required for noggin-induced neonatal myelin repair.
This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder.
Title: Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility
Title: Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.
This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states.
Title: Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance.
Title: Olig1 is expressed in human oligodendrocytes during maturation and regeneration.
analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus
Title: A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.
Observational study of gene-disease association. (HuGE Navigator)
Title: A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.
No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression.
Title: Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.
OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients
Title: Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.
Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification.
Title: Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD13903 (e-PCR)
- UniSTS:294928

ECD02311 (e-PCR)
- UniSTS:283411

ECD12647 (e-PCR)
- UniSTS:293680

ECD24242 (e-PCR)
- UniSTS:305226

ECD16046 (e-PCR)
- UniSTS:297061

ECD01890 (e-PCR)
- UniSTS:282991

REN83708 (e-PCR)
- UniSTS:408506

REN83709 (e-PCR)
- UniSTS:408507

REN83710 (e-PCR)
- UniSTS:408508

REN83711 (e-PCR)
- UniSTS:408509

REN83712 (e-PCR)
- UniSTS:408510

REN83713 (e-PCR)
- UniSTS:408511

REN83714 (e-PCR)
- UniSTS:408512

REN83715 (e-PCR)
- UniSTS:408513

REN83716 (e-PCR)
- UniSTS:408514

REN83717 (e-PCR)
- UniSTS:408515

REN83718 (e-PCR)
- UniSTS:408516

REN83719 (e-PCR)
- UniSTS:408517

REN83720 (e-PCR)
- UniSTS:408518

REN83721 (e-PCR)
- UniSTS:408519

REN83722 (e-PCR)
- UniSTS:408520

REN83723 (e-PCR)
- UniSTS:408521

REN83724 (e-PCR)
- UniSTS:408522

REN83725 (e-PCR)
- UniSTS:408523

REN83726 (e-PCR)
- UniSTS:408524

REN83727 (e-PCR)
- UniSTS:408525

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate commitment	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oligodendrocyte transcription factor 1

Names: basic domain, helix-loop-helix protein, class B, 6; class B basic helix-loop-helix protein 6; class E basic helix-loop-helix protein 21; oligo1; oligodendrocyte lineage transcription factor 1; oligodendrocyte-specific bHLH transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.