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Alppl2 alkaline phosphatase, placental-like 2 [ Mus musculus (house mouse) ]

Gene ID: 11650, updated on 9-Dec-2024

Summary

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Official Symbol
Alppl2provided by MGI
Official Full Name
alkaline phosphatase, placental-like 2provided by MGI
Primary source
MGI:MGI:108009
See related
Ensembl:ENSMUSG00000026246 AllianceGenome:MGI:108009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAP; Akp5; Alpg; D1Ertd816e
Summary
Enables alkaline phosphatase activity. Located in myofibril. Is expressed in early conceptus; intestine; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in genital fat pad adult (RPKM 7.5), testis adult (RPKM 2.2) and 3 other tissues See more
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Genomic context

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See Alppl2 in Genome Data Viewer
Location:
1 C5; 1 44.05 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87014412..87023656, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87086690..87095934, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase pseudogene 1 Neighboring gene predicted gene, 41910 Neighboring gene predicted gene 29371 Neighboring gene alkaline phosphatase, intestinal Neighboring gene alkaline phosphatase 3, intestine, not Mn requiring

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse. Dehghani H, et al. Dev Dyn, 2000 Apr. PMID 10767088
  2. MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice. Wang M, et al. Gene, 2001 Nov 14. PMID 11722850
  3. Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Narisawa S, et al. Dev Dyn, 1997 Mar. PMID 9056646
  4. Central role of pyrophosphate in acellular cementum formation. Foster BL, et al. PLoS One, 2012. PMID 22675556, Free PMC Article
  5. Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes. Manes T, et al. Genomics, 1990 Nov. PMID 2286375

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alkaline phosphatase, germ cell type
Names
alkaline phosphatase 5
embryonic alkaline phosphatase
embryonic-type alkaline phosphatase
NP_031459.3
XP_006529145.1
XP_011246206.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007433.3 → NP_031459.3  alkaline phosphatase, germ cell type precursor

    See identical proteins and their annotated locations for NP_031459.3

    Status: VALIDATED

    Source sequence(s)
    AK145571, BB727113, BC052874, CN717647
    Consensus CDS
    CCDS15126.1
    UniProtKB/Swiss-Prot
    P24823, Q3ULC9
    UniProtKB/TrEMBL
    Q7TPW4
    Related
    ENSMUSP00000027455.7, ENSMUST00000027455.13
    Conserved Domains (1) summary
    pfam00245
    Location:51 → 486
    Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87014412..87023656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529082.3 → XP_006529145.1  alkaline phosphatase, germ cell type isoform X1

    See identical proteins and their annotated locations for XP_006529145.1

    UniProtKB/Swiss-Prot
    P24823, Q3ULC9
    UniProtKB/TrEMBL
    Q7TPW4
    Conserved Domains (1) summary
    pfam00245
    Location:51 → 486
    Alk_phosphatase; Alkaline phosphatase

  2. XM_011247904.3 → XP_011246206.1  alkaline phosphatase, germ cell type isoform X1

    See identical proteins and their annotated locations for XP_011246206.1

    UniProtKB/Swiss-Prot
    P24823, Q3ULC9
    UniProtKB/TrEMBL
    Q7TPW4
    Conserved Domains (1) summary
    pfam00245
    Location:51 → 486
    Alk_phosphatase; Alkaline phosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24823.2 GenPept UniProtKB/Swiss-Prot:P24823

Gene LinkOut

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