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Dlgap2 DLG associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116681, updated on 2-Nov-2024

Summary

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Official Symbol
Dlgap2provided by RGD
Official Full Name
DLG associated protein 2provided by RGD
Primary source
RGD:620224
See related
EnsemblRapid:ENSRNOG00000012573 AllianceGenome:RGD:620224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DAP-2; SAPAP2
Summary
The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. [provided by RefSeq, Jun 2014]
Expression
Restricted expression toward (RPKM 70.0) See more
Orthologs
human mouse all
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Genomic context

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See Dlgap2 in Genome Data Viewer
Location:
16q12.5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (81489059..82198693, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (74786771..75496402, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (79872238..80596977, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482527 Neighboring gene CLN8, transmembrane ER and ERGIC protein Neighboring gene uncharacterized LOC134482419 Neighboring gene short transmembrane mitochondrial protein 1 like 1 Neighboring gene glutamate-rich 1 Neighboring gene uncharacterized LOC134482528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2. Chertkow-Deutsher Y, et al. Int J Neuropsychopharmacol, 2010 Apr. PMID 19793403
  2. Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: Beneficial effect of dextromethorphan. Yang SN, et al. Hippocampus, 2006. PMID 16598705
  3. Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Jiang-Xie LF, et al. Mol Autism, 2014. PMID 25071926, Free PMC Article
  4. Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries. Moore CL, et al. Circ Res, 2014 Apr 11. PMID 24585759, Free PMC Article
  5. Loss of PSD-95 enrichment is not a prerequisite for spine retraction. Woods GF, et al. J Neurosci, 2011 Aug 24. PMID 21865455, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligomeric Abeta25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
    Title: Oligomeric Aβ25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
  2. Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries.
    Title: Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries.
  3. These results suggest that alterations in global methylation pattern are involved in behavioural adaptation to environmental stress and pinpoint Dlgap2 as a possible target in post-traumatic stress.
    Title: DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanylate kinase activity NAS
Non-traceable Author Statement
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GDP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron-neuron synaptic transmission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neurofilament NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane NAS
Non-traceable Author Statement
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disks large-associated protein 2
Names
PSD-95/SAP90-associated protein-2
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
discs large homolog associated protein 2
postsynaptic density 95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053901.2 → NP_446353.3  disks large-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P97837
    UniProtKB/TrEMBL
    A0A8I5ZQT2
    Related
    ENSRNOP00000104191.1, ENSRNOT00000138999.1
    Conserved Domains (1) summary
    pfam03359
    Location:715 → 1059
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    81489059..82198693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094154.2 → XP_038950082.1  disks large-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P97837
    UniProtKB/TrEMBL
    A0A0G2JUI3
    Related
    ENSRNOP00000069108.2, ENSRNOT00000086896.3
    Conserved Domains (1) summary
    pfam03359
    Location:716 → 1060
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_039094157.2 → XP_038950085.1  disks large-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A4U6
    Conserved Domains (1) summary
    pfam03359
    Location:716 → 1046
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. XM_039094156.2 → XP_038950084.1  disks large-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A6IWE1, F1LSL6
    Related
    ENSRNOP00000107136.1, ENSRNOT00000126131.1
    Conserved Domains (1) summary
    pfam03359
    Location:703 → 1047
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. XM_063275039.1 → XP_063131109.1  disks large-associated protein 2 isoform X2

    Related
    ENSRNOP00000111868.1, ENSRNOT00000162694.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97837.3 GenPept UniProtKB/Swiss-Prot:P97837

Gene LinkOut

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