Psmd10 proteasome 26S subunit, non-ATPase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmd10provided by RGD
Official Full Name: proteasome 26S subunit, non-ATPase 10provided by RGD
Primary source: RGD:620350
See related: EnsemblRapid:ENSRNOG00000051669 AllianceGenome:RGD:620350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p28Gank
Summary: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; cytoskeletal protein binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of protein metabolic process; and regulation of DNA-templated transcription. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in several cellular components, including cytoskeleton; neuron projection; and nucleus. Orthologous to human PSMD10 (proteasome 26S subunit, non-ATPase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 104.5), Kidney (RPKM 97.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (109445291..109453605, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (104656809..104665122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (112323188..112328642, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130489 (e-PCR)
- UniSTS:213773

RH129063 (e-PCR)
- UniSTS:212371

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic sequestering of NF-kappaB	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of NF-kappaB	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome regulatory particle assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome regulatory particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 10

Names: 26S proteasome regulatory subunit p28; gankyrin; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411753.1 → NP_001398682.1 26S proteasome non-ATPase regulatory subunit 10 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6HLR0
NM_001411754.1 → NP_001398683.1 26S proteasome non-ATPase regulatory subunit 10 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5XXS7, A6HLQ9, B0BMV9

Related

ENSRNOP00000071909.2, ENSRNOT00000086698.3
NM_053925.2 → NP_446377.2 26S proteasome non-ATPase regulatory subunit 10 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZXW8, A6HLQ8

Related

ENSRNOP00000082840.1, ENSRNOT00000106019.2