Alox15 arachidonate 15-lipoxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alox15provided by MGI
Official Full Name: arachidonate 15-lipoxygenaseprovided by MGI
Primary source: MGI:MGI:87997
See related: Ensembl:ENSMUSG00000018924 AllianceGenome:MGI:87997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO
Summary: Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues See more
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70234973..70279465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70344147..70390538, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells.
Title: Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells.
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Title: Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Title: Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Title: Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis.
Title: Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis.
Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma.
Title: Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma.
12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.
Title: 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.
P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.
Title: P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.
12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study.
Title: 12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study.
Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
Title: Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.

Submit: New GeneRIF Correction See all GeneRIFs (125)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate 12(S)-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 12(S)-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 12(S)-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate 15-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 15-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 15-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables hepoxilin A3 synthase activity	ISO Inferred from Sequence Orthology more info
enables hepoxilin-epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables linoleate 13S-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables linoleate 13S-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables linoleate 13S-lipoxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-13	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-13	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxin A4 biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoxygenase pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of peroxisome proliferator activated receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyunsaturated fatty acid lipoxygenase ALOX15

Names: 12-LOX; 12/15-lipoxygenase; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase

NP_033790.3

EC 1.13.11.12

EC 1.13.11.31

EC 1.13.11.33

XP_006532099.1

EC 1.13.11.12

EC 1.13.11.31

EC 1.13.11.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009660.3 → NP_033790.3 polyunsaturated fatty acid lipoxygenase ALOX15

See identical proteins and their annotated locations for NP_033790.3

Status: VALIDATED

Source sequence(s)

AK142371, AL596096, U04331

Consensus CDS

CCDS24944.1

UniProtKB/Swiss-Prot

P39654, Q4FJY9, Q5F2E3, Q6PHB2

UniProtKB/TrEMBL

A2CF88

Related

ENSMUSP00000019068.7, ENSMUST00000019068.7

Conserved Domains (2) summary

cd01753
Location:2 → 112

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:202 → 654

Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70234973..70279465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532036.5 → XP_006532099.1 polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1

See identical proteins and their annotated locations for XP_006532099.1

Conserved Domains (2) summary

cd01753
Location:32 → 142

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:232 → 684

Lipoxygenase