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ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [ Homo sapiens (human) ]

Gene ID: 116984, updated on 10-Dec-2024

Summary

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Official Symbol
ARAP2provided by HGNC
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by HGNC
Primary source
HGNC:HGNC:16924
See related
Ensembl:ENSG00000047365 MIM:606645; AllianceGenome:HGNC:16924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARX; CENTD1
Summary
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Expression
Broad expression in thyroid (RPKM 5.9), brain (RPKM 5.8) and 22 other tissues See more
Orthologs
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Genomic context

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See ARAP2 in Genome Data Viewer
Location:
4p14
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (36005404..36244784, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (35974325..36213757, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (36007026..36246136, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374397 Neighboring gene uncharacterized LOC124900847 Neighboring gene LIM zinc finger domain containing 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15345 Neighboring gene uncharacterized LOC439933 Neighboring gene death domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21409 Neighboring gene uncharacterized LOC105374399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition. Xu P, et al. J Transl Med, 2022 Jul 16. PMID 35842667, Free PMC Article
  2. Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes. Gavicherla B, et al. Infect Immun, 2010 Nov. PMID 20823205, Free PMC Article
  3. ARAP2 inhibits Akt independently of its effects on focal adhesions. Luo R, et al. Biol Cell, 2018 Dec. PMID 30144359, Free PMC Article
  4. The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic. Chen PW, et al. J Biol Chem, 2014 Oct 31. PMID 25225293, Free PMC Article
  5. ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. Yoon HY, et al. J Cell Sci, 2006 Nov 15. PMID 17077126

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition.
    Title: The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition.
  2. These results highlight an Arf GAP-independent function of ARAP2 in regulating Akt activity.
    Title: ARAP2 inhibits Akt independently of its effects on focal adhesions.
  3. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions.
    Title: The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.
  4. ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology
    Title: ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.
  5. Our findings indicate that ARAP2 promotes InlB-mediated entry of Listeria monocytogenes in part, by antagonizing the host GTPase Arf6.
    Title: Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes.
  6. ARAP2 is an Arf6GAP that functions downstream of RhoA to regulate focal adhesion dynamics.
    Title: ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13675, FLJ44916, KIAA0580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Names
Arf and Rho GAP adapter protein 2
centaurin-delta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015230.4 → NP_056045.2  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_056045.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript and encodes the supported protein.
    Source sequence(s)
    AC098827, AC104078, AY049733, BX104334
    Consensus CDS
    CCDS3441.1
    UniProtKB/Swiss-Prot
    Q4W5D2, Q7Z2L5, Q8WZ64, Q96L70, Q96P49, Q9Y4E4
    UniProtKB/TrEMBL
    A0A2X0SFS3
    Related
    ENSP00000302895.4, ENST00000303965.9
    Conserved Domains (9) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1114 → 1293
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:484 → 576
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:588 → 675
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:892 → 1002
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13257
    Location:1015 → 1110
    PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
    cd13259
    Location:1423 → 1543
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    cd17227
    Location:1325 → 1422
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:680 → 800
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2

RNA

  1. NR_146893.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC098827, AC104078, AC108033, AC109818, AC116623

  2. NR_146894.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104078, AF411982, AY049733, BC150258, BM054835, CB992251

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    36005404..36244784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449575.1 → XP_047305531.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFS3

  2. XM_047449574.1 → XP_047305530.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A2X0SFS3

  3. XM_047449573.1 → XP_047305529.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SFS3

  4. XM_047449572.1 → XP_047305528.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SFS3

  5. XM_047449571.1 → XP_047305527.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q4W5D2, Q7Z2L5, Q8WZ64, Q96L70, Q96P49, Q9Y4E4
    UniProtKB/TrEMBL
    A0A2X0SFS3

  6. XM_047449576.1 → XP_047305532.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X5

RNA

  1. XR_007096351.1 RNA Sequence

  2. XR_007096352.1 RNA Sequence

  3. XR_007096353.1 RNA Sequence

  4. XR_007096350.1 RNA Sequence

  5. XR_007096348.1 RNA Sequence

  6. XR_001741112.3 RNA Sequence

  7. XR_007096349.1 RNA Sequence

  8. XR_001741123.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    35974325..36213757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348862.1 → XP_054204837.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFS3

  2. XM_054348861.1 → XP_054204836.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A2X0SFS3

  3. XM_054348860.1 → XP_054204835.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SFS3

  4. XM_054348859.1 → XP_054204834.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SFS3

  5. XM_054348858.1 → XP_054204833.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFS3

  6. XM_054348863.1 → XP_054204838.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X5

RNA

  1. XR_008486897.1 RNA Sequence

  2. XR_008486898.1 RNA Sequence

  3. XR_008486899.1 RNA Sequence

  4. XR_008486896.1 RNA Sequence

  5. XR_008486894.1 RNA Sequence

  6. XR_008486893.1 RNA Sequence

  7. XR_008486895.1 RNA Sequence

  8. XR_008486900.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139182.1: Suppressed sequence

    Description
    NM_139182.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WZ64.3 GenPept UniProtKB/Swiss-Prot:Q8WZ64

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