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Bex3 brain expressed X-linked 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117089, updated on 17-Aug-2024

Summary

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Official Symbol
Bex3provided by RGD
Official Full Name
brain expressed X-linked 3provided by RGD
Primary source
RGD:3148
See related
EnsemblRapid:ENSRNOG00000028822 AllianceGenome:RGD:3148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nade; Ngfrap1
Summary
Enables nerve growth factor receptor binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Biomarker of glaucoma; transient cerebral ischemia; and visual epilepsy. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 756.7), Brain (RPKM 676.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bex3 in Genome Data Viewer
Location:
Xq32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (104064896..104066425)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (99273270..99274799)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (106823442..106825016)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484140 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 9 Neighboring gene transcription elongation factor A like 9 Neighboring gene developmental pluripotency-associated 4, pseudogene 2 Neighboring gene presenilin-associated rhomboid-like protein, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons. Nadeau JR, et al. Glia, 2014 May. PMID 24616056
  2. Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma? Guo Y, et al. Exp Eye Res, 2009 Dec. PMID 19682984, Free PMC Article
  3. [Expression and significance of p75NTR in dorsal root ganglia in different injury models]. Li F, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008 Dec. PMID 19141972
  4. Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration. Greferath U, et al. Neurosci Lett, 2002 Oct 25. PMID 12377384
  5. Expression of p75NTR and its associated protein NADE in the rat cochlea. Sano H, et al. Laryngoscope, 2001 Mar. PMID 11224788

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bex3 has an important role for the regulation of TrkA expression in neurons.
    Title: Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.
  2. Reducing neuronal p75NTR expression plays a critical role in switching satellite glial cells to a reactive state.
    Title: Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons.
  3. Expression of p75NTR increased in glia, but was downregulated in sensory neurons in sciatic nerve injury and spinal cord injury.
    Title: [Expression and significance of p75NTR in dorsal root ganglia in different injury models].
  4. hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in tuberous sclerosis complex
    Title: The TSC1 gene product hamartin interacts with NADE.
  5. Expression of p75NTR on cholinergic interneurons of the rat striatum is associated with delayed neuronal degeneration.
    Title: Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular function inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nerve growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein BEX3
Names
brain-expressed X-linked protein 3 homolog
nerve growth factor receptor (TNFRSF16) associated protein 1
nerve growth factor receptor-associated protein 1
p75NTR-associated cell death executor
rBex3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398797.1 → NP_001385726.1  protein BEX3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q6PDU5, Q9JIT2
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 126
    BEX; Brain expressed X-linked like family

  2. NM_053401.3 → NP_445853.1  protein BEX3 isoform 1

    See identical proteins and their annotated locations for NP_445853.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    B2GUV1
    Related
    ENSRNOP00000042696.6, ENSRNOT00000045997.6
    Conserved Domains (1) summary
    pfam04538
    Location:2 → 116
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    104064896..104066425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099417.2 → XP_038955345.1  protein BEX3 isoform X1

    UniProtKB/Swiss-Prot
    Q6PDU5, Q9JIT2
    Related
    ENSRNOP00000082465.2, ENSRNOT00000101693.2
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 126
    BEX; Brain expressed X-linked like family

  2. XM_039099418.2 → XP_038955346.1  protein BEX3 isoform X2

    UniProtKB/TrEMBL
    B2GUV1
    Conserved Domains (1) summary
    pfam04538
    Location:2 → 116
    BEX; Brain expressed X-linked like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDU5.1 GenPept UniProtKB/Swiss-Prot:Q6PDU5

Gene LinkOut

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