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Ivns1abp influenza virus NS1A binding protein [ Mus musculus (house mouse) ]

Gene ID: 117198, updated on 12-May-2024

Summary

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Official Symbol
Ivns1abpprovided by MGI
Official Full Name
influenza virus NS1A binding proteinprovided by MGI
Primary source
MGI:MGI:2152389
See related
Ensembl:ENSMUSG00000023150 AllianceGenome:MGI:2152389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND1; NS-1; Nd1-L; Nd1-S; NS1-BP; HSPC068; mKIAA0850; 1190004M08Rik; 1700126I16Rik
Summary
Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 79.1), CNS E11.5 (RPKM 71.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ivns1abp in Genome Data Viewer
Location:
1 G1; 1 64.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151220237..151240196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151344486..151364445)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47996 Neighboring gene STARR-positive B cell enhancer ABC_E4356 Neighboring gene STARR-seq mESC enhancer starr_02612 Neighboring gene predicted gene, 46162 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:153134717-153134870 Neighboring gene STARR-seq mESC enhancer starr_02614 Neighboring gene STARR-seq mESC enhancer starr_02615 Neighboring gene predicted gene 10138 Neighboring gene STARR-positive B cell enhancer ABC_E3312 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153191350-153191651 Neighboring gene STARR-positive B cell enhancer ABC_E3313 Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene tRNA methyltransferase 1 like Neighboring gene microRNA 7682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors. Lin Y, et al. DNA Cell Biol, 2018 Oct. PMID 30124330
  2. A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism. Ohta Y, et al. Int J Oncol, 2010 Feb. PMID 20043078
  3. Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy. Matsudo Y, et al. Transgenic Res, 2006 Oct. PMID 16952015
  4. Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts. Inoue A, et al. DNA Cell Biol, 2005 Jan. PMID 15684717
  5. Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments. Sasagawa K, et al. J Biol Chem, 2002 Nov 15. PMID 12213805

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
    Title: Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
  2. Overexpression of short variant form of new Kelch family protein ND1 leads to erythroid and megakaryocyte dysplasia by targeting megakaryocyte-erythroid progenitors.
    Title: Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors.
  3. Nd1-L is involved in invasion and metastasis of cancer cells by regulating the actin cytoskeleton and Rho family proteins.
    Title: A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism.
  4. Nd1-S may play a role in cell cycle progression in the nucleus.
    Title: Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts.
  5. Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton
    Title: Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments.
  6. Plays a critical role in protecting the heart from doxorubicin-induced cardiomyopathy.
    Title: Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
influenza virus NS1A-binding protein homolog
Names
ND1-L2
NS1-binding protein homolog
kelch family protein Nd1
kelch family protein Nd1-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039511.1 → NP_001034600.1  influenza virus NS1A-binding protein homolog isoform 1

    See identical proteins and their annotated locations for NP_001034600.1

    Status: VALIDATED

    Source sequence(s)
    AC115060, AK007291, AL355706
    Consensus CDS
    CCDS35735.1
    UniProtKB/Swiss-Prot
    Q920Q8
    Related
    ENSMUSP00000107518.4, ENSMUST00000111887.10
    Conserved Domains (2) summary
    cd18306
    Location:14 → 137
    BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
    cd18502
    Location:129 → 221
    BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

  2. NM_001039512.1 → NP_001034601.1  influenza virus NS1A-binding protein homolog isoform 3

    See identical proteins and their annotated locations for NP_001034601.1

    Status: VALIDATED

    Source sequence(s)
    AC115060, AK144835, AL355706
    Consensus CDS
    CCDS15358.1
    UniProtKB/Swiss-Prot
    Q920Q8
    Related
    ENSMUSP00000095150.2, ENSMUST00000097543.8
    Conserved Domains (6) summary
    smart00612
    Location:472 → 517
    Kelch; Kelch domain
    PHA03098
    Location:23 → 596
    PHA03098; kelch-like protein; Provisional
    cd14735
    Location:129 → 181
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam01344
    Location:553 → 593
    Kelch_1; Kelch motif

  3. NM_001359262.1 → NP_001346191.1  influenza virus NS1A-binding protein homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165946
    Conserved Domains (3) summary
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:553 → 593
    Kelch_1; Kelch motif
    cl28614
    Location:3 → 549
    BTB; Broad-Complex, Tramtrack and Bric a brac

  4. NM_001359263.1 → NP_001346192.1  influenza virus NS1A-binding protein homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC165946
    UniProtKB/TrEMBL
    Q06BK5
    Conserved Domains (3) summary
    smart00612
    Location:88 → 134
    Kelch; Kelch domain
    PHA03098
    Location:136 → 357
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:221 → 264
    Kelch; KELCH repeat [structural motif]

  5. NM_054102.2 → NP_473443.2  influenza virus NS1A-binding protein homolog isoform 2

    See identical proteins and their annotated locations for NP_473443.2

    Status: VALIDATED

    Source sequence(s)
    AC115060, AK146494, AL355706
    Consensus CDS
    CCDS15359.1
    UniProtKB/Swiss-Prot
    Q06BK6, Q3TXI1, Q3UJE3, Q3UJS1, Q3UKH9, Q3UMK9, Q6ZQ34, Q920Q8, Q99KN0, Q9D978
    Related
    ENSMUSP00000023918.7, ENSMUST00000023918.13
    Conserved Domains (3) summary
    sd00038
    Location:502 → 545
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:595 → 635
    Kelch_1; Kelch motif
    cl28614
    Location:23 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    151220237..151240196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529089.4 → XP_006529152.1  influenza virus NS1A-binding protein homolog isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:209 → 255
    Kelch; Kelch domain
    PHA03098
    Location:257 → 478
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:342 → 385
    Kelch; KELCH repeat [structural motif]

  2. XM_030243144.1 → XP_030099004.1  influenza virus NS1A-binding protein homolog isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:209 → 255
    Kelch; Kelch domain
    PHA03098
    Location:257 → 478
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:342 → 385
    Kelch; KELCH repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028582.2: Suppressed sequence

    Description
    NM_028582.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920Q8.2 GenPept UniProtKB/Swiss-Prot:Q920Q8

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