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Dnah9 dynein, axonemal, heavy chain 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117251, updated on 10-Oct-2024

Summary

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Symbol
Dnah9provided by RGD
Full Name
dynein, axonemal, heavy chain 9provided by RGD
Primary source
RGD:621799
See related
EnsemblRapid:ENSRNOG00000004171 AllianceGenome:RGD:621799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Predicted to act upstream of or within cerebrospinal fluid circulation and mucociliary clearance. Predicted to be located in 9+2 motile cilium and distal portion of axoneme. Predicted to be part of outer dynein arm. Predicted to be active in axoneme and motile cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 59.4), Brain (RPKM 23.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnah9 in Genome Data Viewer
Location:
10q24
Exon count:
72
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50996796..51363977, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (50496174..50864909, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (52351226..52711289, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene THAP domain-containing protein 5-like Neighboring gene mitogen activated protein kinase kinase 4 Neighboring gene zinc finger protein 18 Neighboring gene uncharacterized LOC120095122 Neighboring gene shisa family member 6 Neighboring gene uncharacterized LOC134480810 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus. Fassad MR, et al. Am J Hum Genet, 2018 Dec 6. PMID 30471717, Free PMC Article
  2. Axonemal dynein expression in human fetal tracheal epithelium. Carson JL, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Mar. PMID 11839535
  3. Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis. Reed W, et al. Am J Respir Cell Mol Biol, 2000 Dec. PMID 11104725
  4. Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia. Fliegauf M, et al. Am J Respir Crit Care Med, 2005 Jun 15. PMID 15750039, Free PMC Article
  5. DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm. Loges NT, et al. Am J Hum Genet, 2008 Nov. PMID 18950741, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cerebrospinal fluid circulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mucociliary clearance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in distal portion of axoneme ISO
Inferred from Sequence Orthology
more info
  
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
part_of outer dynein arm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 9
Names
dynein heavy chain 9, axonemal
dynein, axonemal, heavy polypeptide 9
mCG140381-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427097.1 → NP_001414026.1  dynein axonemal heavy chain 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000005583.9, ENSRNOT00000005583.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    50996796..51363977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087294.2 → XP_038943222.1  dynein axonemal heavy chain 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A869
    Conserved Domains (6) summary
    COG5245
    Location:1422 → 4053
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:2970 → 3313
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 692
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1195 → 1601
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1735 → 2061
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4092 → 4387
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_039087292.2 → XP_038943220.1  dynein axonemal heavy chain 9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A869
    Conserved Domains (6) summary
    COG5245
    Location:1517 → 4097
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3014 → 3357
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1645
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1779 → 2105
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4136 → 4431
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_039087293.2 → XP_038943221.1  dynein axonemal heavy chain 9 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A869
    Conserved Domains (6) summary
    COG5245
    Location:1517 → 4072
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4111 → 4406
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_039087295.2 → XP_038943223.1  dynein axonemal heavy chain 9 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A869
    Conserved Domains (6) summary
    COG5245
    Location:1194 → 3825
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:2742 → 3085
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:2 → 464
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:967 → 1373
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1507 → 1833
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3864 → 4159
    Dynein_C; Dynein heavy chain C-terminal domain

  5. XM_039087300.2 → XP_038943228.1  dynein axonemal heavy chain 9 isoform X10

    Conserved Domains (4) summary
    COG5245
    Location:87 → 2405
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:1322 → 1665
    MT; Microtubule-binding stalk of dynein motor
    pfam12774
    Location:87 → 413
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:2444 → 2739
    Dynein_C; Dynein heavy chain C-terminal domain

  6. XM_039087302.2 → XP_038943230.1  dynein axonemal heavy chain 9 isoform X12

    Conserved Domains (9) summary
    pfam12777
    Location:739 → 1082
    MT; Microtubule-binding stalk of dynein motor
    pfam17857
    Location:323 → 422
    AAA_lid_1; AAA+ lid domain
    pfam03028
    Location:1567 → 1687
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12775
    Location:111 → 290
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:467 → 726
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:1109 → 1323
    AAA_9; ATP-binding dynein motor region D5
    pfam17852
    Location:5 → 104
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam18198
    Location:1701 → 1855
    AAA_lid_11; Dynein heavy chain AAA lid domain
    pfam18199
    Location:1861 → 2156
    Dynein_C; Dynein heavy chain C-terminal domain

  7. XM_039087303.2 → XP_038943231.1  dynein axonemal heavy chain 9 isoform X13

    Conserved Domains (9) summary
    pfam12777
    Location:724 → 1067
    MT; Microtubule-binding stalk of dynein motor
    pfam17857
    Location:308 → 407
    AAA_lid_1; AAA+ lid domain
    pfam03028
    Location:1552 → 1672
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam12775
    Location:96 → 275
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:452 → 711
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:1094 → 1308
    AAA_9; ATP-binding dynein motor region D5
    pfam17852
    Location:1 → 89
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam18198
    Location:1686 → 1840
    AAA_lid_11; Dynein heavy chain AAA lid domain
    pfam18199
    Location:1846 → 2141
    Dynein_C; Dynein heavy chain C-terminal domain

  8. XM_017597645.3 → XP_017453134.1  dynein axonemal heavy chain 9 isoform X5

    UniProtKB/TrEMBL
    F1LV07

  9. XM_039087296.2 → XP_038943224.1  dynein axonemal heavy chain 9 isoform X6

    UniProtKB/TrEMBL
    F1LV07
    Conserved Domains (7) summary
    COG5245
    Location:1517 → 3710
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam03028
    Location:3893 → 4013
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2793 → 3052
    AAA_8; P-loop containing dynein motor region D4

  10. XM_039087297.2 → XP_038943225.1  dynein axonemal heavy chain 9 isoform X7

    UniProtKB/TrEMBL
    F1LV07
    Conserved Domains (7) summary
    COG5245
    Location:1517 → 3710
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam03028
    Location:3893 → 3913
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2793 → 3052
    AAA_8; P-loop containing dynein motor region D4

  11. XM_039087298.2 → XP_038943226.1  dynein axonemal heavy chain 9 isoform X8

    UniProtKB/TrEMBL
    F1LV07
    Conserved Domains (6) summary
    COG5245
    Location:1517 → 3710
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2793 → 3052
    AAA_8; P-loop containing dynein motor region D4

  12. XM_063268325.1 → XP_063124395.1  dynein axonemal heavy chain 9 isoform X9

  13. XM_039087301.2 → XP_038943229.1  dynein axonemal heavy chain 9 isoform X11

    UniProtKB/TrEMBL
    A6HFG1
    Conserved Domains (4) summary
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    cl38936
    Location:2144 → 2279
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_005490291.2 RNA Sequence

  2. XR_005490292.2 RNA Sequence

  3. XR_005490293.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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