Ang3 angiogenin, ribonuclease A family, member 3 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ang3provided by MGI
Official Full Name: angiogenin, ribonuclease A family, member 3provided by MGI
Primary source: MGI:MGI:1201793
See related: AllianceGenome:MGI:1201793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Angl; Ef-5; Rnase5c
Summary: Enables RNA nuclease activity. Predicted to be involved in several processes, including activation of phospholipase A2 activity; activation of protein kinase B activity; and defense response to other organism. Predicted to be located in several cellular components, including actin cytoskeleton; basement membrane; and nucleolus. Predicted to be part of angiogenin-PRI complex. Predicted to be active in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Note: For NCBI build 37.1 and 37.2, GeneID:11730 was placed on chr 14 at NC_000080.5:44534733..44540744(+), which is the intended location of GeneID:503844. GeneID:11730 represents a locus that is missing from the C57BL/6 assembly but is found in BALB/c. [17 Jun 2014]; not in current annotation release
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Genomic context

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Location:: 14; 14 C1

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structures of two more murine Ang paralogues, mAng-2 and mAng-3 reveal homology with the human homologues.
Title: Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494610

NoName (e-PCR)
- UniSTS:493017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to yeast	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
part_of angiogenin-PRI complex	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiogenin-3

Names: angiogenin related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.