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CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]

Gene ID: 1178, updated on 14-Nov-2024

Summary

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Official Symbol
CLCprovided by HGNC
Official Full Name
Charcot-Leyden crystal galectinprovided by HGNC
Primary source
HGNC:HGNC:2014
See related
Ensembl:ENSG00000105205 MIM:153310; AllianceGenome:HGNC:2014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 112.7), urinary bladder (RPKM 16.5) and 5 other tissues See more
Orthologs
all
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Genomic context

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See CLC in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39731255..39738029, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42535528..42542305, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40221895..40228669, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene galectin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene leucine twenty homeobox Neighboring gene uncharacterized LOC124904719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters. Sato T, et al. J Dermatol Sci, 2023 Oct. PMID 37640566
  2. Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution. Swaminathan GJ, et al. Biochemistry, 1999 Oct 19. PMID 10529229
  3. The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes. Dyer KD, et al. Genomics, 1997 Mar 1. PMID 9119387
  4. Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins. Leonidas DD, et al. Structure, 1995 Dec 15. PMID 8747464
  5. Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily. Ackerman SJ, et al. J Immunol, 1993 Jan 15. PMID 8419478

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters.
    Title: Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters.
  2. Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.
    Title: Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.
  3. Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
    Title: Behçet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
  4. Galectin-10 as a Potential Biomarker for Eosinophilic Diseases.
    Title: Galectin-10 as a Potential Biomarker for Eosinophilic Diseases.
  5. Crystalline State Determines the Potency of Galectin-10 Protein Assembly to Induce Inflammation.
    Title: Crystalline State Determines the Potency of Galectin-10 Protein Assembly to Induce Inflammation.
  6. Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).
    Title: Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).
  7. Identification of galectin10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid.
    Title: Identification of galectin‑10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid.
  8. [Expression and pathological role of galectin-10 in different types of nasal polyps].
    Title: [Expression and pathological role of galectin-10 in different types of nasal polyps].
  9. Galectin-10, the protein that forms Charcot-Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils.
    Title: Galectin-10, the protein that forms Charcot-Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils.
  10. Increased CLC/Gal-10 and MBP-1 levels in the sputum were strongly correlated with sputum eosinophils in patients with asthma. CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.
    Title: Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT contributes_to lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of T cell anergy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
galectin-10
Names
Charcot-Leyden crystal protein
eosinophil lysophospholipase
lectin, galactoside-binding, soluble, 10
lysolecithin acylhydrolase
NP_001819.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046978.1 RefSeqGene

    Range
    5001..11775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001828.6 → NP_001819.2  galectin-10

    See identical proteins and their annotated locations for NP_001819.2

    Status: REVIEWED

    Source sequence(s)
    AV715261, AV762486, AW292557
    Consensus CDS
    CCDS33025.1
    UniProtKB/Swiss-Prot
    C5HZ13, C5HZ14, Q05315, Q0VDE3
    Related
    ENSP00000221804.3, ENST00000221804.5
    Conserved Domains (1) summary
    pfam00337
    Location:5 → 137
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39731255..39738029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42535528..42542305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05315.3 GenPept UniProtKB/Swiss-Prot:Q05315

Gene LinkOut

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