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Art2a ADP-ribosyltransferase 2a [ Mus musculus (house mouse) ]

Gene ID: 11871, updated on 4-Jan-2025

Summary

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Official Symbol
Art2aprovided by MGI
Official Full Name
ADP-ribosyltransferase 2aprovided by MGI
Primary source
MGI:MGI:107546
See related
Ensembl:ENSMUSG00000092517 AllianceGenome:MGI:107546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rt6; Rt-6; ARTC2; Ly92a; Rt6-1; Art2a-ps
Summary
Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in large intestine adult (RPKM 1.5), spleen adult (RPKM 0.9) and 9 other tissues See more
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Genomic context

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See Art2a in Genome Data Viewer
Location:
7 E2; 7 54.6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101201657..101210072, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101552453..101560865, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 2A, cGMP-stimulated Neighboring gene microRNA 139 Neighboring gene predicted gene, 35363 Neighboring gene STARR-positive B cell enhancer ABC_E6576 Neighboring gene STARR-seq mESC enhancer starr_19694 Neighboring gene predicted gene, 19765 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene ADP-ribosyltransferase 2b Neighboring gene predicted gene, 45995

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide and deduced amino acid sequence for the mouse homologue of the rat T-cell differentiation marker RT6. Koch F, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2362814, Free PMC Article
  2. Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F1 mice. Koch-Nolte F, et al. Int Immunol, 1995 May. PMID 7547715
  3. Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity. Hara N, et al. J Biochem, 2000 Oct. PMID 11011142
  4. Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase. Hara N, et al. Eur J Biochem, 1999 Jan. PMID 9914505
  5. Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Ohlrogge W, et al. Mol Cell Biol, 2002 Nov. PMID 12370300, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism.
    Title: NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway.
  2. Extracellular nicotinamide adenine dinucleotide (NAD) acts via ART2.1 to regulate P2X7 purinergic receptor-dependent inflammatory responses in murine macrophages.
    Title: Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
  3. identify ART2.1 as a new candidate for linking autocrine/paracrine activation of inflammatory macrophages to the release of NAD, a critical intracellular metabolite
    Title: Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.
  4. Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect.
    Title: Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
  5. ART2a is required for ADP-ribosylation of cell surface proteins
    Title: Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
  6. CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2.
    Title: CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
T-cell ecto-ADP-ribosyltransferase 1
Names
ADP-ribosyltransferase 2a, pseudogene
ADP-ribosyltransferase C2 and C3 toxin-like 2
NAD(+) glycohydrolase
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
T-cell differentiation marker Rt6 homolog 1
T-cell mono(ADP-ribosyl)transferase 1
mono(ADP-ribosyl)transferase 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007490.1 → NP_031516.1  T-cell ecto-ADP-ribosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_031516.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) encodes the functional protein. This variant is found in BALB/c mice but not in C57BL/6J mice.
    Source sequence(s)
    X52991
    UniProtKB/Swiss-Prot
    O35278, P17981, Q0VB79, Q64173
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 242
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_033804.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is found in C57BL/6J mice but not in BALB/c mice.
    Source sequence(s)
    AC129609, AK018555
    Related
    ENSMUST00000173420.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101201657..101210072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17981.2 GenPept UniProtKB/Swiss-Prot:P17981

Gene LinkOut

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