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ZFYVE27 zinc finger FYVE-type containing 27 [ Homo sapiens (human) ]

Gene ID: 118813, updated on 2-Nov-2024

Summary

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Official Symbol
ZFYVE27provided by HGNC
Official Full Name
zinc finger FYVE-type containing 27provided by HGNC
Primary source
HGNC:HGNC:26559
See related
Ensembl:ENSG00000155256 MIM:610243; AllianceGenome:HGNC:26559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG33; PROTRUDIN
Summary
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in small intestine (RPKM 6.9), duodenum (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZFYVE27 in Genome Data Viewer
Location:
10q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97737128..97760895)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98617284..98641047)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99496885..99520652)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99478816-99479636 Neighboring gene MARVEL domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99519797-99520296 Neighboring gene Sharpr-MPRA regulatory region 10521 Neighboring gene Sharpr-MPRA regulatory region 10024 Neighboring gene secreted frizzled related protein 5 Neighboring gene uncharacterized LOC107984260 Neighboring gene GOLGA7B divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:99599631-99600830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of ZFYVE27/protrudin in hereditary spastic paraplegia. Martignoni M, et al. Am J Hum Genet, 2008 Jul. PMID 18606302, Free PMC Article
  2. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. Petrova V, et al. Nat Commun, 2020 Nov 5. PMID 33154382, Free PMC Article
  3. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Mannan AU, et al. Am J Hum Genet, 2006 Aug. PMID 16826525, Free PMC Article
  4. Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. Pedersen NM, et al. J Cell Biol, 2020 Aug 3. PMID 32479595, Free PMC Article
  5. Role of spastin and protrudin in neurite outgrowth. Zhang C, et al. J Cell Biochem, 2012 Jul. PMID 22573551

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
    Title: Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
  2. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
    Title: Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
  3. Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
    Title: Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
  4. Protrudin modulates seizure activity through GABAA receptor regulation.
    Title: Protrudin modulates seizure activity through GABA(A) receptor regulation.
  5. SPG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER proteins, and functions in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
    Title: Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.
  6. findings indicate that protrudin interacts with spastin and induces axon formation through its N-terminal domain. Moreover, protrudin and spastin may work together to play an indispensable role in motor axon outg
    Title: Role of spastin and protrudin in neurite outgrowth.
  7. Protrudin-KIF5 complex contributes to the vesicular transport in neurons.
    Title: Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  9. VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth.
    Title: Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.
  10. The role of ZFYVE27/protrudin in hereditary spastic paraplegia is reported.
    Title: The role of ZFYVE27/protrudin in hereditary spastic paraplegia.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hereditary spastic paraplegia 33
MedGen: C1853251 OMIM: 610244 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotrophin TRK receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotrophin TRK receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in growth cone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protrudin
Names
spastic paraplegia 33 protein
zinc finger FYVE domain containing 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017075.1 RefSeqGene

    Range
    5008..28775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002261.4 → NP_001002261.1  protrudin isoform 1

    See identical proteins and their annotated locations for NP_001002261.1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS31262.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Conserved Domains (1) summary
    cd15723
    Location:354 → 414
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  2. NM_001002262.4 → NP_001002262.1  protrudin isoform 3

    See identical proteins and their annotated locations for NP_001002262.1

    Status: REVIEWED

    Source sequence(s)
    AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
    Consensus CDS
    CCDS31264.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000353069.3, ENST00000359980.5
    Conserved Domains (1) summary
    cd15723
    Location:342 → 402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  3. NM_001174119.2 → NP_001167590.1  protrudin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53562.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000337993.7, ENST00000337540.11
    Conserved Domains (1) summary
    cd15723
    Location:310 → 370
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  4. NM_001174120.2 → NP_001167591.1  protrudin isoform 5

    See identical proteins and their annotated locations for NP_001167591.1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53563.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000350148.4, ENST00000357540.8
    Conserved Domains (1) summary
    cd15723
    Location:256 → 316
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  5. NM_001174121.2 → NP_001167592.1  protrudin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53565.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000359642.3, ENST00000370610.7
    Conserved Domains (1) summary
    cd15723
    Location:249 → 309
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  6. NM_001174122.2 → NP_001167593.1  protrudin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53564.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000359646.3, ENST00000370613.7
    Conserved Domains (1) summary
    cd15723
    Location:224 → 284
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  7. NM_001385871.1 → NP_001372800.1  protrudin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS31262.1
    Related
    ENSP00000409594.2, ENST00000423811.3
    Conserved Domains (1) summary
    cd15723
    Location:354 → 414
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  8. NM_001385875.1 → NP_001372804.1  protrudin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS31263.1
    UniProtKB/Swiss-Prot
    B7Z3S0, B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q5T4F4, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
    Related
    ENSP00000506975.1, ENST00000684270.1
    Conserved Domains (1) summary
    cd15723
    Location:349 → 409
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  9. NM_001385876.1 → NP_001372805.1  protrudin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:360 → 420
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  10. NM_001385877.1 → NP_001372806.1  protrudin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:348 → 408
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  11. NM_001385878.1 → NP_001372807.1  protrudin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347 → 407
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  12. NM_001385879.1 → NP_001372808.1  protrudin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347 → 407
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  13. NM_001385880.1 → NP_001372809.1  protrudin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS31264.1
    Conserved Domains (1) summary
    cd15723
    Location:342 → 402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  14. NM_001385881.1 → NP_001372810.1  protrudin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342 → 402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  15. NM_001385882.1 → NP_001372811.1  protrudin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347 → 389
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  16. NM_001385883.1 → NP_001372812.1  protrudin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342 → 384
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  17. NM_001385884.1 → NP_001372813.1  protrudin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342 → 384
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  18. NM_001385885.1 → NP_001372814.1  protrudin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:322 → 382
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  19. NM_001385886.1 → NP_001372815.1  protrudin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315 → 375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  20. NM_001385887.1 → NP_001372816.1  protrudin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315 → 375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  21. NM_001385888.1 → NP_001372817.1  protrudin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315 → 375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  22. NM_001385889.1 → NP_001372818.1  protrudin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:310 → 370
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  23. NM_001385890.1 → NP_001372819.1  protrudin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:286 → 346
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  24. NM_001385891.1 → NP_001372820.1  protrudin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:286 → 346
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  25. NM_001385892.1 → NP_001372821.1  protrudin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL358938
    UniProtKB/TrEMBL
    A0A0S2Z627
    Conserved Domains (1) summary
    cd15723
    Location:281 → 341
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  26. NM_001385893.1 → NP_001372822.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279 → 339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  27. NM_001385894.1 → NP_001372823.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279 → 339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  28. NM_001385895.1 → NP_001372824.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279 → 339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  29. NM_001385896.1 → NP_001372825.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    UniProtKB/TrEMBL
    A0A0S2Z5V0
    Conserved Domains (1) summary
    cd15723
    Location:274 → 334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  30. NM_001385897.1 → NP_001372826.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    UniProtKB/TrEMBL
    A0A0S2Z5V0
    Conserved Domains (1) summary
    cd15723
    Location:274 → 334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  31. NM_001385898.1 → NP_001372827.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    UniProtKB/TrEMBL
    A0A0S2Z5V0
    Conserved Domains (1) summary
    cd15723
    Location:274 → 334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  32. NM_001385899.1 → NP_001372828.1  protrudin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:270 → 330
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  33. NM_001385900.1 → NP_001372829.1  protrudin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:270 → 330
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  34. NM_001385901.1 → NP_001372830.1  protrudin isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268 → 328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  35. NM_001385902.1 → NP_001372831.1  protrudin isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268 → 328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  36. NM_001385903.1 → NP_001372832.1  protrudin isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268 → 328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  37. NM_001385904.1 → NP_001372833.1  protrudin isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268 → 328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  38. NM_001385905.1 → NP_001372834.1  protrudin isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263 → 323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  39. NM_001385906.1 → NP_001372835.1  protrudin isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263 → 323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  40. NM_001385908.1 → NP_001372837.1  protrudin isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263 → 323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  41. NM_001385911.1 → NP_001372840.1  protrudin isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:261 → 321
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  42. NM_001385915.1 → NP_001372844.1  protrudin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53565.1
    Conserved Domains (1) summary
    cd15723
    Location:249 → 309
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  43. NM_001385916.1 → NP_001372845.1  protrudin isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:231 → 291
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  44. NM_001385918.1 → NP_001372847.1  protrudin isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:231 → 291
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  45. NM_001385919.1 → NP_001372848.1  protrudin isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:131 → 191
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  46. NM_144588.7 → NP_653189.3  protrudin isoform 2

    See identical proteins and their annotated locations for NP_653189.3

    Status: REVIEWED

    Source sequence(s)
    AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
    Consensus CDS
    CCDS31263.1
    UniProtKB/Swiss-Prot
    B7Z3S0, B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q5T4F4, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
    Related
    ENSP00000377282.3, ENST00000393677.8
    Conserved Domains (1) summary
    cd15723
    Location:349 → 409
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

RNA

  1. NR_169794.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  2. NR_169795.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  3. NR_169796.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  4. NR_169797.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  5. NR_169798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  6. NR_169799.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  7. NR_169800.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  8. NR_169801.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  9. NR_169802.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  10. NR_169803.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  11. NR_169804.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  12. NR_169805.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  13. NR_169806.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  14. NR_169808.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  15. NR_169809.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  16. NR_169810.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

  17. NR_169811.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    97737128..97760895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539252.3 → XP_011537554.1  protrudin isoform X1

    Conserved Domains (1) summary
    cd15723
    Location:354 → 396
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  2. XM_011539253.3 → XP_011537555.1  protrudin isoform X2

    Conserved Domains (1) summary
    cd15723
    Location:347 → 389
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

  3. XM_017015646.2 → XP_016871135.1  protrudin isoform X5

    UniProtKB/TrEMBL
    B7Z6J9

  4. XM_017015644.1 → XP_016871133.1  protrudin isoform X3

  5. XM_017015645.1 → XP_016871134.1  protrudin isoform X4

  6. XM_047424567.1 → XP_047280523.1  protrudin isoform X6

RNA

  1. XR_945594.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    98617284..98641047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364723.1 → XP_054220698.1  protrudin isoform X1

  2. XM_054364724.1 → XP_054220699.1  protrudin isoform X2

  3. XM_054364727.1 → XP_054220702.1  protrudin isoform X5

  4. XM_054364725.1 → XP_054220700.1  protrudin isoform X3

  5. XM_054364726.1 → XP_054220701.1  protrudin isoform X4

  6. XM_054364728.1 → XP_054220703.1  protrudin isoform X6

RNA

  1. XR_008488162.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T4F4.1 GenPept UniProtKB/Swiss-Prot:Q5T4F4

Gene LinkOut

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