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CMKLR1 chemerin chemokine-like receptor 1 [ Homo sapiens (human) ]

Gene ID: 1240, updated on 2-Nov-2024

Summary

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Official Symbol
CMKLR1provided by HGNC
Official Full Name
chemerin chemokine-like receptor 1provided by HGNC
Primary source
HGNC:HGNC:2121
See related
Ensembl:ENSG00000174600 MIM:602351; AllianceGenome:HGNC:2121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEZ; ERV1; RVER1; ChemR23; CHEMERINR
Summary
Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues See more
Orthologs
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Genomic context

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See CMKLR1 in Genome Data Viewer
Location:
12q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108288046..108339311, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108256268..108307509, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108681823..108733088, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903078 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3G-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108697351-108697872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108699443-108699964 Neighboring gene Sharpr-MPRA regulatory region 8395 Neighboring gene Sharpr-MPRA regulatory region 632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108732521-108733144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108739700-108740200 Neighboring gene MPRA-validated peak1933 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108780158-108781357 Neighboring gene Sharpr-MPRA regulatory region 8786 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108811567-108812766 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835174-108835930 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835931-108836688 Neighboring gene MPRA-validated peak1935 silencer Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108906844-108907029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910488-108910988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910989-108911489 Neighboring gene FIC domain protein adenylyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
    Title: GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
  2. Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
    Title: Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
  3. Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
    Title: Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
  4. ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
    Title: ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
  5. [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
    Title: [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
  6. Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
    Title: Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
  7. Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
    Title: Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
  8. Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
    Title: Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
  9. Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
    Title: Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
  10. The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
    Title: The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.
EBI GWAS Catalog
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of chemokine-like receptor 1 (CMKLR1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126105, MGC126106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables adipokinetic hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
chemerin-like receptor 1
Names
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
chemerin receptor
chemokine receptor-like 1
chemokine-like receptor 1
orphan G-protein coupled receptor, Dez
resolvin E1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142343.2 → NP_001135815.1  chemerin-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC009729, AC063957, BC106927, DA466082
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
    UniProtKB/TrEMBL
    Q05KQ8
    Related
    ENSP00000449716.1, ENST00000550402.6
    Conserved Domains (1) summary
    cd15116
    Location:41 → 327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001142344.2 → NP_001135816.1  chemerin-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
    Source sequence(s)
    AC009729, AC063957, AK291800
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
    UniProtKB/TrEMBL
    Q05KQ8
    Related
    ENSP00000311733.7, ENST00000312143.11
    Conserved Domains (1) summary
    cd15116
    Location:41 → 327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001142345.2 → NP_001135817.1  chemerin-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
    Source sequence(s)
    AC009729, AC063957, DA939526
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
    UniProtKB/TrEMBL
    Q05KQ8
    Related
    ENSP00000401293.1, ENST00000412676.5
    Conserved Domains (1) summary
    cd15116
    Location:41 → 327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_004072.3 → NP_004063.1  chemerin-like receptor 1 isoform b

    See identical proteins and their annotated locations for NP_004063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC009729, DA466082, U79527
    Consensus CDS
    CCDS41829.1
    UniProtKB/TrEMBL
    Q05KQ8
    Related
    ENSP00000447579.1, ENST00000552995.5
    Conserved Domains (1) summary
    pfam00001
    Location:55 → 314
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108288046..108339311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428313.1 → XP_047284269.1  chemerin-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108256268..108307509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371128.1 → XP_054227103.1  chemerin-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99788.2 GenPept UniProtKB/Swiss-Prot:Q99788

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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Tools
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