Ccnb2 cyclin B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnb2provided by MGI
Official Full Name: cyclin B2provided by MGI
Primary source: MGI:MGI:88311
See related: Ensembl:ENSMUSG00000032218 AllianceGenome:MGI:88311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CycB2
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including T cell homeostasis; meiosis I cell cycle process; and thymus development. Located in cytoplasm and membrane. Is expressed in several structures, including blastocyst; central nervous system; early embryo; gonad; and placenta. Orthologous to human CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14.5 (RPKM 72.5), liver E14 (RPKM 70.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 39.53 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (70314971..70328836, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (70407689..70421554, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma.
Title: Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma.
5'-UTR and ORF elements, as well as the 3'-UTR regulate the translation of Cyclin.
Title: 5'-UTR and ORF elements, as well as the 3'-UTR regulate the translation of Cyclin.
CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.
Title: CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.
results indicate that cyclin B2/CDK1 is also responsible for separase inhibition via inhibitory phosphorylation to regulate chromosome separation in oocyte meiosis, which may not occur in other cell types.
Title: The cyclin B2/CDK1 complex inhibits separase activity in mouse oocyte meiosis I.
These results have revealed a hidden compensatory mechanism between Cyclin B1 and Cyclin B2 in regulating MPF and oocyte meiotic resumption.
Title: Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.
Rate of translation of Cyclin B1 and B2 proteins, together with their degradation, is a major determinant of their divergent temporal accumulation during oocyte maturation. The Cdk1-independent translation of Ccnb2 mRNA strongly suggest that this Cyclin is present in prophase and may play a critical role in setting the stockpile of Cyclin B protein for the assembly of pre-maturation promoting factor.
Title: The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.
Report roles for cyclin B2 and p53 in centrosome separation that may be perturbed in many human cancers.
Title: Cyclin B2 and p53 control proper timing of centrosome separation.
Hec1-dependent cyclin B2 stabilization during early metaphase is important for early-stage spindle assembly.
Title: Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes.
Menin may inhibit MEN1 insulinoma by suppressing cyclin B2 expression via histone modification.
Title: [The role and mechanism of high expression of cyclin B2 in MEN1 insulinoma].
this study identifies a correlation between the presence of AIRE and proteasomal breakdown of cyclin B2, which leads us to speculate that cyclin B2 could be a target of AIRE's E3-ubiquitin ligase activity
Title: AIRE1A might be involved in cyclin B2 degradation in testicular lysates.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548204

PMC22491P1 (e-PCR)
- UniSTS:272112

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G2/MI transition of meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G2/MI transition of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spindle assembly involved in female meiosis I	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spindle assembly involved in female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.