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SLC5A10 solute carrier family 5 member 10 [ Homo sapiens (human) ]

Gene ID: 125206, updated on 14-Nov-2024

Summary

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Official Symbol
SLC5A10provided by HGNC
Official Full Name
solute carrier family 5 member 10provided by HGNC
Primary source
HGNC:HGNC:23155
See related
Ensembl:ENSG00000154025 MIM:618636; AllianceGenome:HGNC:23155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT5; SGLT-5
Summary
This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue See more
Orthologs
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Genomic context

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See SLC5A10 in Genome Data Viewer
Location:
17p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18950676..19022565)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18897202..18970458)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18853989..18925878)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11846 Neighboring gene small nucleolar RNA MBII-202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18850561-18851174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18851175-18851788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18864393-18865390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866439-18866973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866974-18867507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18871247-18872190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18874077-18875018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18883844-18884799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18884800-18885754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18885755-18886709 Neighboring gene family with sequence similarity 83 member G Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8282 Neighboring gene Sharpr-MPRA regulatory region 2479 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18917397-18918386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18934086-18934883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18935718-18936468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18936469-18937218 Neighboring gene GRB2 related adaptor protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18954567-18955068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18955069-18955568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:18966649-18967243 Neighboring gene small nucleolar RNA, C/D box 3B-1 Neighboring gene small nucleolar RNA, C/D box 3B-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia. Diederich J, et al. Cell Mol Life Sci, 2023 Aug 18. PMID 37594549, Free PMC Article
  2. Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study. Loomis SJ, et al. Sci Rep, 2019 Apr 11. PMID 30976018, Free PMC Article
  3. Fingerprints of hSGLT5 sugar and cation selectivity. Ghezzi C, et al. Am J Physiol Cell Physiol, 2014 May 1. PMID 24573086
  4. Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. Grempler R, et al. FEBS Lett, 2012 Feb 3. PMID 22212718
  5. Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members. Chen J, et al. Diabetes Ther, 2010 Dec. PMID 22127746, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia.
    Title: SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia.
  2. Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study.
    Title: Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study.
  3. Results show that rs2257609 C>T is located in the intron region of SLC5A10 and is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients. The rs2257609 C>T variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2.
    Title: Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
  4. hSGLT5 is a sodium/mannose transporter that is blocked by phlorizin. Li(+) and H(+) ions were also able to drive mannose transport, and transport was electrogenic.
    Title: Fingerprints of hSGLT5 sugar and cation selectivity.
  5. SGLT-5 as a kidney mannose transporter
    Title: Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables mannose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannose:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:sodium symporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sodium/mannose cotransporter SLC5A10
Names
Na(+)/glucose cotransporter 5
sodium/glucose cotransporter 5
solute carrier family 5 (sodium/glucose cotransporter), member 10
solute carrier family 5 (sodium/sugar cotransporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042450.4 → NP_001035915.1  sodium/mannose cotransporter SLC5A10 isoform 2

    See identical proteins and their annotated locations for NP_001035915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, BC034380, BP332461, DR003789
    Consensus CDS
    CCDS42275.1
    UniProtKB/Swiss-Prot
    A0PJK1, A8MUC9, B4DPI0, B7WPR4, Q6P5X0, Q8IXM4, Q96LQ1
    Related
    ENSP00000379007.3, ENST00000395645.4
    Conserved Domains (1) summary
    cd11489
    Location:17 → 596
    SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

  2. NM_001270648.3 → NP_001257577.1  sodium/mannose cotransporter SLC5A10 isoform 3

    See identical proteins and their annotated locations for NP_001257577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, BC062617, BP332461
    Consensus CDS
    CCDS59278.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000379005.2, ENST00000395643.6
    Conserved Domains (1) summary
    cl00456
    Location:17 → 569
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001270649.2 → NP_001257578.1  sodium/mannose cotransporter SLC5A10 isoform 4

    See identical proteins and their annotated locations for NP_001257578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, AK298345, BC062617, BP332461, DR003789
    Consensus CDS
    CCDS59277.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000401875.2, ENST00000417251.6
    Conserved Domains (1) summary
    cl00456
    Location:17 → 560
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001282417.1 → NP_001269346.1  sodium/mannose cotransporter SLC5A10 isoform 5

    See identical proteins and their annotated locations for NP_001269346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has many differences in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 5, which has a shorter N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AA745934, BC034380, BC039868
    Consensus CDS
    CCDS74008.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000324346.6, ENST00000317977.10
    Conserved Domains (1) summary
    cl00456
    Location:1 → 566
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_152351.6 → NP_689564.3  sodium/mannose cotransporter SLC5A10 isoform 1

    See identical proteins and their annotated locations for NP_689564.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA745934, AC003957, AK057946, BC034380
    Consensus CDS
    CCDS11201.2
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000379008.2, ENST00000395647.6
    Conserved Domains (1) summary
    cd11489
    Location:17 → 612
    SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18950676..19022565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024191.3 → XP_016879680.2  sodium/mannose cotransporter SLC5A10 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:17 → 649
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    18897202..18970458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315079.1 → XP_054171054.1  sodium/mannose cotransporter SLC5A10 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0PJK1.2 GenPept UniProtKB/Swiss-Prot:A0PJK1

Gene LinkOut

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