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CNGA4 cyclic nucleotide gated channel subunit alpha 4 [ Homo sapiens (human) ]

Gene ID: 1262, updated on 10-Dec-2024

Summary

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Official Symbol
CNGA4provided by HGNC
Official Full Name
cyclic nucleotide gated channel subunit alpha 4provided by HGNC
Primary source
HGNC:HGNC:2152
See related
Ensembl:ENSG00000132259 MIM:609472; AllianceGenome:HGNC:2152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
Summary
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.8), lung (RPKM 0.7) and 3 other tissues See more
Orthologs
mouse all
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Genomic context

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See CNGA4 in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6234793..6244976)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6293180..6303456)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6260319..6265709)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 42 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene MPRA-validated peak1186 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:6291386-6292585 Neighboring gene cholecystokinin B receptor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:6324771-6325489 Neighboring gene uncharacterized LOC101927825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6340407-6341144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4336 Neighboring gene caveolae associated protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Munger SD, et al. Science, 2001 Dec 7. PMID 11739959, Free PMC Article
  2. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Kelliher KR, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12649326, Free PMC Article
  3. Nomenclature for ion channel subunits. Bradley J, et al. Science, 2001 Dec 7. PMID 11764791, Free PMC Article
  4. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Hofmann F, et al. Pharmacol Rev, 2005 Dec. PMID 16382102
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126168, MGC126169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi-associated vesicle membrane TAS
Traceable Author Statement
more info
  
located_in ciliary membrane TAS
Traceable Author Statement
more info
  
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclic nucleotide-gated channel alpha-4
Names
CNG channel alpha-4
cyclic nucleotide gated channel alpha 4
cyclic nucleotide gated channel beta 2
cyclic nucleotide-gated cation channel alpha-4
olfactory cyclic nucleotide-gated channel subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037329.4 → NP_001032406.1  cyclic nucleotide-gated channel alpha-4

    See identical proteins and their annotated locations for NP_001032406.1

    Status: VALIDATED

    Source sequence(s)
    AC022762, AK122736, DB238337
    Consensus CDS
    CCDS31408.1
    UniProtKB/Swiss-Prot
    Q8IV77
    Related
    ENSP00000369268.2, ENST00000379936.3
    Conserved Domains (3) summary
    cd00038
    Location:348 → 464
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:34 → 273
    Ion_trans; Ion transport protein
    pfam16526
    Location:464 → 535
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6234793..6244976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017219.2 → XP_016872708.1  cyclic nucleotide-gated channel alpha-4 isoform X2

  2. XM_017017218.3 → XP_016872707.1  cyclic nucleotide-gated channel alpha-4 isoform X2

  3. XM_024448353.2 → XP_024304121.1  cyclic nucleotide-gated channel alpha-4 isoform X3

    Conserved Domains (3) summary
    cd00038
    Location:308 → 424
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:1 → 233
    Ion_trans; Ion transport protein
    pfam16526
    Location:424 → 495
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  4. XM_017017217.2 → XP_016872706.1  cyclic nucleotide-gated channel alpha-4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6293180..6303456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367688.1 → XP_054223663.1  cyclic nucleotide-gated channel alpha-4 isoform X1

  2. XM_054367691.1 → XP_054223666.1  cyclic nucleotide-gated channel alpha-4 isoform X2

  3. XM_054367689.1 → XP_054223664.1  cyclic nucleotide-gated channel alpha-4 isoform X1

  4. XM_054367690.1 → XP_054223665.1  cyclic nucleotide-gated channel alpha-4 isoform X4

    UniProtKB/Swiss-Prot
    Q8IV77

  5. XM_054367692.1 → XP_054223667.1  cyclic nucleotide-gated channel alpha-4 isoform X2

  6. XM_054367693.1 → XP_054223668.1  cyclic nucleotide-gated channel alpha-4 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IV77.3 GenPept UniProtKB/Swiss-Prot:Q8IV77

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