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LOC127272401 NANOG-H3K27ac hESC enhancer GRCh37_chr2:3615875-3616480 [ Homo sapiens (human) ]

Gene ID: 127272401, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127272401
Gene description
NANOG-H3K27ac hESC enhancer GRCh37_chr2:3615875-3616480
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127272401 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (3568285..3568890)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (3590809..3591414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (3615875..3616480)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:3583482-3584681 Neighboring gene ribonuclease H1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3607689-3608586 Neighboring gene RNASEH1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15233 Neighboring gene uncharacterized LOC124907726 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:3616481-3617087 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:3617088-3617693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3622403-3622978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:3622979-3623555 Neighboring gene ribosomal protein S7 Neighboring gene collectin subfamily member 11 Neighboring gene NANOG hESC enhancer GRCh37_chr2:3662665-3663169 Neighboring gene TMSB4X pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_094252.1 

    Range
    101..706
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    3568285..3568890
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    3590809..3591414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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