U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127402814 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43039303-43039843 [ Homo sapiens (human) ]

Gene ID: 127402814, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127402814
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43039303-43039843
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127402814 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43039201..43039912)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43292063..43292774)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43039303..43040014)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC643977 Neighboring gene uncharacterized LOC105374746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22518 Neighboring gene Sharpr-MPRA regulatory region 2050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43000051-43000552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43000553-43001052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43007431-43008283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43010287-43010787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22520 Neighboring gene ANXA2R overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43018214-43018736 Neighboring gene uncharacterized LOC105374748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43033815-43034354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43034355-43034892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43042769-43043306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43043307-43043842 Neighboring gene ANXA2R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43044419-43044918 Neighboring gene annexin A2 receptor Neighboring gene Sharpr-MPRA regulatory region 2707 Neighboring gene uncharacterized LOC100132356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22532

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 22524
  • ATAC-STARR-seq lymphoblastoid active region 22525

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_104763.2 

    Range
    101..812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43039201..43039912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43292063..43292774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases