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LOC127458473 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1859957-1860559 [ Homo sapiens (human) ]

Gene ID: 127458473, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127458473
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1859957-1860559
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127458473 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (1911791..1912393)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (1689865..1690467)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (1859957..1860559)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762347-1762848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1762849-1763348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1764028-1764696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1764697-1765364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1776960-1777876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1777877-1778792 Neighboring gene microRNA 596 Neighboring gene Rho guanine nucleotide exchange factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1781498-1781998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1783384-1783975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1788613-1789492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1789493-1790372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1790373-1791250 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1791725-1792924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1813026-1813858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1821545-1822256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1829183-1829682 Neighboring gene Sharpr-MPRA regulatory region 1960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:1854442-1855641 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1856650-1856751 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:1864189-1864688 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1870370-1871569 Neighboring gene uncharacterized LOC100131395 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1894594-1894745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1897836-1898336 Neighboring gene KBTBD11 antisense RNA 1 Neighboring gene KBTBD11 overlapping transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_113246.1 

    Range
    101..703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    1911791..1912393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187576.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    95167..95769
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    1689865..1690467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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