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LOC127458743 NANOG hESC enhancer GRCh37_chr8:12758236-12758737 [ Homo sapiens (human) ]

Gene ID: 127458743, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127458743
Gene description
NANOG hESC enhancer GRCh37_chr8:12758236-12758737
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127458743 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (12900727..12901228)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (13166893..13167394)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3019 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12651516-12652033 Neighboring gene long intergenic non-protein coding RNA 681 Neighboring gene uncharacterized LOC105379289 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12726438-12727079 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12799399-12799938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12808376-12808876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18955 Neighboring gene regulator of solute carriers 1 pseudogene Neighboring gene tRNA methyltransferase 9B (putative) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12829815-12830334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:12834091-12834678 Neighboring gene uncharacterized LOC124901889 Neighboring gene Sharpr-MPRA regulatory region 1393

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_113512.1 

    Range
    101..602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    12900727..12901228
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    6096092..6096593
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    13166893..13167394
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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