U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127458752 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980809-12981441 [ Homo sapiens (human) ]

Gene ID: 127458752, updated on 27-Aug-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127458752
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980809-12981441
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (13123300..13123932)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (13389772..13390404)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12915937-12916437 Neighboring gene RNA, U6 small nuclear 842, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:12947375-12948574 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:12957644-12958023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12962666-12963312 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12965381-12965880 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980176-12980808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982170-12982670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982671-12983171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18957 Neighboring gene DLC1 Rho GTPase activating protein Neighboring gene uncharacterized LOC101930149 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:13223844-13225043 Neighboring gene MT-ND4 pseudogene 7 Neighboring gene uncharacterized LOC124901890

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_113521.1 

    Range
    101..733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    13123300..13123932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    6318898..6319533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    13389772..13390404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases