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LOC127459897 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90547639-90548190 [ Homo sapiens (human) ]

Gene ID: 127459897, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127459897
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90547639-90548190
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127459897 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (89535410..89535961)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (90658313..90658864)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90547639..90548190)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr8:90264022-90264523 Neighboring gene Sharpr-MPRA regulatory region 15400 Neighboring gene ribosomal protein SA pseudogene 74 Neighboring gene NANOG hESC enhancer GRCh37_chr8:90354032-90354548 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90365894-90367093 Neighboring gene keratin 8 pseudogene 4 Neighboring gene LINE-1 retrotransposable element ORF2 protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27599 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:90623836-90625035 Neighboring gene uncharacterized LOC112268015 Neighboring gene NANOG hESC enhancer GRCh37_chr8:90737932-90738481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:90749405-90749994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19345 Neighboring gene palmitic acid regulated anti-inflammatory lncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_114666.1 

    Range
    101..652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    89535410..89535961
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    90658313..90658864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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