U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127825088 H3K27ac hESC enhancer GRCh37_chr12:112123487-112124188 [ Homo sapiens (human) ]

Gene ID: 127825088, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127825088
Gene description
H3K27ac hESC enhancer GRCh37_chr12:112123487-112124188
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127825088 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (111685683..111686384)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (111662604..111663305)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112123487..112124188)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903020 Neighboring gene BRCA1 associated protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112122083-112122784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112122785-112123486 Neighboring gene PEST containing nuclear protein pseudogene 1 Neighboring gene acyl-CoA dehydrogenase family member 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112194124-112194765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112195407-112196048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112196049-112196688 Neighboring gene NANOG hESC enhancer GRCh37_chr12:112199468-112200003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112204196-112204965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112210937-112211508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112228790-112229715 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112229716-112230640 Neighboring gene microRNA 6761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112272338-112273217 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7041 Neighboring gene MAPK activated protein kinase 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 4874

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126601.1 

    Range
    101..802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    111685683..111686384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    111662604..111663305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases