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LOC127830045 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70796359-70796882 [ Homo sapiens (human) ]

Gene ID: 127830045, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127830045
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70796359-70796882
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes three accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127830045 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (70504020..70504543)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (68326565..68327088)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (70796359..70796882)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70593533-70594034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70615294-70615813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70636737-70637238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70654349-70654848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70670319-70670820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70670821-70671320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70687219-70687723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70690391-70690891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70698815-70699316 Neighboring gene uncharacterized LOC124903519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70719956-70720463 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:70727798-70728001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70752651-70753150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70785141-70785685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70795833-70796358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9697 Neighboring gene long intergenic non-protein coding RNA 2205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70809116-70809692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9698 Neighboring gene uncharacterized LOC107984781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9699 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70871773-70872576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70877919-70878863 Neighboring gene long intergenic non-protein coding RNA 2204

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 9693
  • ATAC-STARR-seq lymphoblastoid active region 9694
  • ATAC-STARR-seq lymphoblastoid active region 9695

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_131527.1 

    Range
    101..624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    70504020..70504543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    68326565..68327088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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