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LOC127888270 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77173286-77173965 [ Homo sapiens (human) ]

Gene ID: 127888270, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127888270
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77173286-77173965
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127888270 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (79177204..79177883)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (80072335..80073014)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77173286..77173965)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77040047-77040547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:77042736-77043935 Neighboring gene Sharpr-MPRA regulatory region 5335 Neighboring gene C1q and TNF related 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77094193-77094906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77099175-77100160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77112846-77113750 Neighboring gene endo-beta-N-acetylglucosaminidase Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77157651-77158151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77179359-77180239 Neighboring gene uncharacterized LOC124904069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9080 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77188893-77189550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77198565-77199383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77207229-77207739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77219238-77219738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77219739-77220239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77223705-77224476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77362366-77362866 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:77369816-77369979 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:77397348-77397522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77400039-77400540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77403781-77404282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77404283-77404782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77409324-77409841 Neighboring gene Sharpr-MPRA regulatory region 4769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77505025-77505682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77528471-77529242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77529243-77530014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77544533-77545032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77645285-77645791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77655553-77656543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77657995-77658740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77665156-77666000 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77669291-77669891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77673338-77673922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77675499-77676019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77680917-77681538 Neighboring gene microRNA 4739

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_137874.1 

    Range
    101..780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    79177204..79177883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    80072335..80073014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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