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LOC127894536 NANOG hESC enhancer GRCh37_chr21:33315105-33315606 [ Homo sapiens (human) ]

Gene ID: 127894536, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127894536
Gene description
NANOG hESC enhancer GRCh37_chr21:33315105-33315606
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127894536 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (31942793..31943294)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30310982..30311485)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33315105..33315606)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104777-33105416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104135-33104776 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33106899-33107074 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33119263-33119514 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:33126139-33126731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33172518-33173018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33173019-33173519 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33200433-33200620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33253321-33253821 Neighboring gene TPT1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33280341-33280874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33284969-33285779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:33303660-33304223 Neighboring gene hormonally up-regulated Neu-associated kinase Neighboring gene NANOG hESC enhancer GRCh37_chr21:33346858-33347382 Neighboring gene long intergenic non-protein coding RNA 159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33506465-33506966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18359 Neighboring gene MIS18 kinetochore protein A Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33650609-33651110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33651111-33651610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_144190.1 

    Range
    101..602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    31942793..31943294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    30310982..30311485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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