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LOC127895748 OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28532907-28533662 [ Homo sapiens (human) ]

Gene ID: 127895748, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127895748
Gene description
OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28532907-28533662
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K4me1 histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127895748 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (28136919..28137674)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (28598331..28599086)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28532907..28533662)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene TTC28 antisense RNA 1 Neighboring gene microRNA 3199-1 Neighboring gene microRNA 3199-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28376696-28377276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28388821-28389342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28389343-28389862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28391245-28391744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28415419-28415960 Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene RNA, 7SL, cytoplasmic 757, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:28508589-28509131 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:28604851-28606050 Neighboring gene small nucleolar RNA SNORD42 Neighboring gene NANOG hESC enhancer GRCh37_chr22:28643774-28644398 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:28711524-28712723 Neighboring gene VISTA enhancer hs1645 Neighboring gene Sharpr-MPRA regulatory region 5107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28805414-28805914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28838691-28839638 Neighboring gene microRNA 5739

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_145322.1 

    Range
    101..856
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    28136919..28137674
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    28598331..28599086
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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