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LOC128316818 H3K4me1 hESC enhancer GRCh37_chr21:45643225-45643724 [ Homo sapiens (human) ]

Gene ID: 128316818, updated on 10-Oct-2023

Summary

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Gene symbol
LOC128316818
Gene description
H3K4me1 hESC enhancer GRCh37_chr21:45643225-45643724
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC128316818 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44223342..44223841)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42577407..42577908)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45595498-45596144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45596145-45596790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45600775-45601276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45601277-45601776 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45616066-45616566 to GRCh37_chr21:45616069-45616569 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45616946-45617124 Neighboring gene uncharacterized LOC105372832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45621734-45622497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45622498-45623260 Neighboring gene uncharacterized LOC102725065 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:45626388-45627587 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45627759-45628259 and GRCh37_chr21:45627787-45628287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45628433-45629348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45633361-45633860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45642723-45643224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45645682-45646182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45646183-45646683 Neighboring gene inducible T cell costimulator ligand Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45659303-45660081 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG and IFNGR2 regulatory element GRCh37_chr21:45660637-45661636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45662586-45663124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45667417-45668358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669258-45669773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669774-45670290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45670291-45670805 Neighboring gene DNMT3L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45676001-45676989 Neighboring gene DNA methyltransferase 3 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:45677884-45678384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45681495-45682054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45685919-45686548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45686549-45687178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45691192-45691798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18564 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:45702827-45703430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45703431-45704032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704033-45704636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704637-45705238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18567 Neighboring gene autoimmune regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_149422.1 

    Range
    101..600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44223342..44223841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42577407..42577908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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