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Crygc crystallin, gamma C [ Mus musculus (house mouse) ]

Gene ID: 12966, updated on 15-Aug-2024

Summary

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Official Symbol
Crygcprovided by MGI
Official Full Name
crystallin, gamma Cprovided by MGI
Primary source
MGI:MGI:88523
See related
Ensembl:ENSMUSG00000025952 AllianceGenome:MGI:88523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cryg-5
Summary
Predicted to be a structural constituent of eye lens. Acts upstream of or within camera-type eye development. Predicted to be located in cytoplasm and nucleus. Is expressed in eye; ileum; reproductive system; and urogenital sinus. Used to study cataract 2 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 2 multiple types. Orthologous to human CRYGC (crystallin gamma C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward genital fat pad adult (RPKM 15.1) See more
Orthologs
human all
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Genomic context

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See Crygc in Genome Data Viewer
Location:
1 C2; 1 32.81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65110684..65112691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65071525..65073532, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene crystallin, gamma E Neighboring gene STARR-seq mESC enhancer starr_01171 Neighboring gene STARR-seq mESC enhancer starr_01172 Neighboring gene crystallin, gamma D Neighboring gene STARR-seq mESC enhancer starr_01173 Neighboring gene crystallin, gamma B Neighboring gene malic enzyme, supernatant pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Wu Y, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315440
  2. Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles. Purkiss AG, et al. J Mol Biol, 2007 Sep 7. PMID 17659303, Free PMC Article
  3. A 6-bp deletion in the Crygc gene leading to a nuclear and radial cataract in the mouse. Graw J, et al. Invest Ophthalmol Vis Sci, 2002 Jan. PMID 11773036
  4. Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins. Graw J, et al. Gene, 1993 Dec 22. PMID 8293998
  5. A 1-bp deletion in the gammaC-crystallin leads to dominant cataracts in mice. Zhao L, et al. Mamm Genome, 2010 Aug. PMID 20686773

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a 1-bp deletion in gammaC-crystallin leads to cataract.
    Title: A 1-bp deletion in the gammaC-crystallin leads to dominant cataracts in mice.
  2. presence of measurable interactions between MIP26 and all crystallins, with the extent of interactions decreasing from alphaA- and alphaB-crystallin to betaB2- and gammaC-crystallin.
    Title: Confocal fluorescence microscopy study of interaction between lens MIP26/AQP0 and crystallins in living cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (2)  1 citation
  • Endonuclease-mediated (1) 
  • Spontaneous (3)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-crystallin C
Names
gamma-C-crystallin
gammaC-crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082573.2 → NP_001076042.1  gamma-crystallin C isoform 2

    See identical proteins and their annotated locations for NP_001076042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which has one additional amino acid compared to isoform 1.
    Source sequence(s)
    CJ066821, CK627566, EF426302
    Consensus CDS
    CCDS35600.1
    UniProtKB/TrEMBL
    A3RLD5
    Related
    ENSMUSP00000109698.2, ENSMUST00000114064.3
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:90 → 171
    Crystall; Beta/Gamma crystallin

  2. NM_007775.2 → NP_031801.1  gamma-crystallin C isoform 1

    See identical proteins and their annotated locations for NP_031801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    CJ066821, CK627566, EF426301
    Consensus CDS
    CCDS15012.1
    UniProtKB/Swiss-Prot
    Q03739, Q61597
    UniProtKB/TrEMBL
    A3RLD4
    Related
    ENSMUSP00000027089.9, ENSMUST00000027089.15
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:89 → 170
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65110684..65112691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61597.3 GenPept UniProtKB/Swiss-Prot:Q61597

Gene LinkOut

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