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LOC129660037 ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 [ Homo sapiens (human) ]

Gene ID: 129660037, updated on 14-Oct-2023

Summary

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Gene symbol
LOC129660037
Gene description
ReSE screen-validated silencer GRCh37_chrX:1599821-1599989
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region is found within pseudoautosomal region 1 (PAR1) of chromosomes X and Y, where each chromosome contains the same DNA region. This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129660037 in Genome Data Viewer
Location:
X;Y
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1480928..1481096)
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1480928..1481096)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1344788..1344956)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene P2Y receptor family member 8 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene P2Y receptor family member 8 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157076.1 

    Range
    101..269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1480928..1481096
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1480928..1481096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1344788..1344956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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