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LOC129663537 ReSE screen-validated silencer GRCh37_chr15:30318078-30318268 [ Homo sapiens (human) ]

Gene ID: 129663537, updated on 14-Oct-2023

Summary

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Gene symbol
LOC129663537
Gene description
ReSE screen-validated silencer GRCh37_chr15:30318078-30318268
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663537 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (30025875..30026065)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (27817611..27817801)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tight junction protein 1 Neighboring gene uncharacterized LOC124903451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30164609-30165110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30165111-30165610 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:30171032-30171214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:30215957-30216506 Neighboring gene Sharpr-MPRA regulatory region 13292 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:30226175-30227374 Neighboring gene non-SMC condensin I complex subunit G pseudogene 2 Neighboring gene synaptogyrin 2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:30375577-30376156 Neighboring gene RNA, 7SL, cytoplasmic 673, pseudogene Neighboring gene golgin A8 family member J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160543.1 

    Range
    101..291
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    30025875..30026065
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p14 PATCHES

    Range
    2198598..2198788
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132920.1 Reference GRCh38.p14 PATCHES

    Range
    13549..13739
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2311082..2311272
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    27817611..27817801
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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