U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crygf crystallin, gamma F [ Mus musculus (house mouse) ]

Gene ID: 12969, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Crygfprovided by MGI
Official Full Name
crystallin, gamma Fprovided by MGI
Primary source
MGI:MGI:88526
See related
Ensembl:ENSMUSG00000025945 AllianceGenome:MGI:88526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Len-2; Cryg-2; DGcry-2; 3110001K11Rik
Summary
Predicted to be a structural constituent of eye lens. Acts upstream of or within eye development. Is expressed in eye; head; and lens. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 C3; 1 33.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65965681..65967470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65926522..65928311)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57567 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 16B pseudogene Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01181 Neighboring gene STARR-seq mESC enhancer starr_01182 Neighboring gene cell growth-regulating nucleolar protein Neighboring gene predicted gene 8812

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity. Graw J, et al. Invest Ophthalmol Vis Sci, 2002 Sep. PMID 12202521
  2. Developmental regulation and cell type-specific expression of the murine gamma F-crystallin gene is mediated through a lens-specific element containing the gamma F-1 binding site. Goring DR, et al. Dev Dyn, 1993 Feb. PMID 8364223
  3. Functional interactions between retinoic acid receptor-related orphan nuclear receptor (ROR alpha) and the retinoic acid receptors in the regulation of the gamma F-crystallin promoter. Tini M, et al. J Biol Chem, 1995 Aug 25. PMID 7650034
  4. Novel zinc finger proteins that interact with the mouse gamma F-crystallin promoter and are expressed in the sclerotome during early somitogenesis. Liu Q, et al. Dev Biol, 1994 Sep. PMID 8088434
  5. Lens-specific promoter activity of a mouse gamma-crystallin gene. Lok S, et al. Mol Cell Biol, 1985 Sep. PMID 3837188, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crygf(Rop) is the first mutation affecting the Crygf gene.
    Title: Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gamma-crystallin F
Names
gamma-F-crystallin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360779.1 → NP_001347708.1  gamma-crystallin F isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK013953, CA326162, CA452192
    Consensus CDS
    CCDS87841.1
    UniProtKB/TrEMBL
    E9Q3I1
    Related
    ENSMUSP00000109661.3, ENSMUST00000114027.3
    Conserved Domains (1) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins

  2. NM_027010.3 → NP_081286.1  gamma-crystallin F isoform 1

    See identical proteins and their annotated locations for NP_081286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK013953, CA326162
    Consensus CDS
    CCDS15018.1
    UniProtKB/Swiss-Prot
    Q9CXV3
    UniProtKB/TrEMBL
    A2RTH4
    Related
    ENSMUSP00000027082.5, ENSMUST00000027082.11
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:89 → 170
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65965681..65967470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXV3.3 GenPept UniProtKB/Swiss-Prot:Q9CXV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools