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Dab1 disabled 1 [ Mus musculus (house mouse) ]

Gene ID: 13131, updated on 27-Nov-2024

Summary

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Official Symbol
Dab1provided by MGI
Official Full Name
disabled 1provided by MGI
Primary source
MGI:MGI:108554
See related
Ensembl:ENSMUSG00000028519 AllianceGenome:MGI:108554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
scm; scr; yot; mDab1; scrambler; C630028C02Rik
Summary
Enables signaling adaptor activity. Involved in nervous system development; reelin-mediated signaling pathway; and regulation of synapse maturation. Acts upstream of or within several processes, including adult walking behavior; negative regulation of neurogenesis; and nervous system development. Located in perinuclear region of cytoplasm. Is active in cytoplasm and glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 14.1), whole brain E14.5 (RPKM 10.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Dab1 in Genome Data Viewer
Location:
4 C6; 4 47.79 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (103476425..104602041)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103619500..104744844)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 25877 Neighboring gene predicted gene, 36604 Neighboring gene STARR-seq mESC enhancer starr_10943 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36661 Neighboring gene STARR-seq mESC enhancer starr_10944 Neighboring gene STARR-seq mESC enhancer starr_10945 Neighboring gene STARR-seq mESC enhancer starr_10949 Neighboring gene STARR-seq mESC enhancer starr_10950 Neighboring gene complement component 8, beta polypeptide Neighboring gene complement component 8, alpha polypeptide Neighboring gene FYN binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders. Teixeira CM, et al. Neuropsychopharmacology, 2014 Feb. PMID 24030361, Free PMC Article
  2. Neurologic function during developmental and adult stages in Dab1(scm) (scrambler) mutant mice. Jacquelin C, et al. Behav Brain Res, 2012 Jan 1. PMID 21945093
  3. Identification of disabled-1 as a candidate gene for critical period neuroplasticity in cat and mouse visual cortex. Yang CB, et al. Eur J Neurosci, 2006 May. PMID 16817883
  4. Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. Olson EC, et al. J Neurosci, 2006 Feb 8. PMID 16467525, Free PMC Article
  5. Spontaneous alternation and spatial learning in Dab1scm (scrambler) mutant mice. Jacquelin C, et al. Brain Res Bull, 2012 Mar 10. PMID 22245534

See all (276) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development.
    Title: Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development.
  2. Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1[-/-](yotari) Mice.
    Title: Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1(-/-)(yotari) Mice.
  3. Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice.
    Title: Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice.
  4. Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
    Title: Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
  5. Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
    Title: Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
  6. A Homozygous Dab1(-/-) Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract.
    Title: A Homozygous Dab1(-/-) Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract.
  7. Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
    Title: Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
  8. Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.
    Title: Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.
  9. Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
    Title: Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
  10. Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
    Title: Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding TAS
Traceable Author Statement
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cerebellum structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex radially oriented cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex radially oriented cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within motor neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within radial glia guided migration of Purkinje cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within radial glia guided migration of Purkinje cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in radial glia guided migration of Purkinje cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within radial glia-guided pyramidal neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reelin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral spinal cord development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disabled homolog 1
Names
yotari

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369046.1 → NP_001355975.1  disabled homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 5, encodes isoform 2.
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Consensus CDS
    CCDS18413.1
    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    UniProtKB/TrEMBL
    B2RRQ8
    Conserved Domains (2) summary
    PRK07764
    Location:255 → 436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  2. NM_001369047.1 → NP_001355976.1  disabled homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2 and 4, encodes isoform 2.
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Consensus CDS
    CCDS18413.1
    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    UniProtKB/TrEMBL
    B2RRQ8
    Conserved Domains (2) summary
    PRK07764
    Location:255 → 436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  3. NM_001369048.1 → NP_001355977.1  disabled homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Consensus CDS
    CCDS89790.1
    Related
    ENSMUSP00000102440.2, ENSMUST00000106827.8
    Conserved Domains (1) summary
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  4. NM_001369049.1 → NP_001355978.1  disabled homolog 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (4).
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  5. NM_010014.3 → NP_034144.1  disabled homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_034144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BE947086, BY264959, Y08381
    UniProtKB/Swiss-Prot
    P97318
    Related
    ENSMUSP00000102439.2, ENSMUST00000106826.8
    Conserved Domains (1) summary
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  6. NM_177259.4 → NP_796233.2  disabled homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_796233.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 4 and 5, encodes isoform 2.
    Source sequence(s)
    AK045616, BC138538, BE945099, BY264959, Y08379
    Consensus CDS
    CCDS18413.1
    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    UniProtKB/TrEMBL
    B2RRQ8
    Related
    ENSMUSP00000102443.3, ENSMUST00000106830.9
    Conserved Domains (2) summary
    PRK07764
    Location:255 → 436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

RNA

  1. NR_104385.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL627134, AL645483, AL669938

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    103476425..104602041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163642.1 → XP_036019535.1  disabled homolog 1 isoform X5

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  2. XM_036163645.1 → XP_036019538.1  disabled homolog 1 isoform X15

    Conserved Domains (1) summary
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  3. XM_006502725.5 → XP_006502788.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502788.1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  4. XM_036163638.1 → XP_036019531.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  5. XM_036163640.1 → XP_036019533.1  disabled homolog 1 isoform X4

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    UniProtKB/TrEMBL
    B2RRQ8
    Conserved Domains (2) summary
    PRK07764
    Location:255 → 436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  6. XM_036163635.1 → XP_036019528.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  7. XM_011240426.3 → XP_011238728.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011238728.1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  8. XM_036163636.1 → XP_036019529.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  9. XM_030253166.2 → XP_030109026.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  10. XM_036163637.1 → XP_036019530.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  11. XM_036163641.1 → XP_036019534.1  disabled homolog 1 isoform X5

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  12. XM_036163633.1 → XP_036019526.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  13. XM_036163632.1 → XP_036019525.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  14. XM_030253165.2 → XP_030109025.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  15. XM_017319948.2 → XP_017175437.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  16. XM_030253172.2 → XP_030109032.1  disabled homolog 1 isoform X5

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  17. XM_006502727.5 → XP_006502790.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502790.1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  18. XM_030253170.2 → XP_030109030.1  disabled homolog 1 isoform X4

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    UniProtKB/TrEMBL
    B2RRQ8
    Conserved Domains (2) summary
    PRK07764
    Location:255 → 436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  19. XM_030253175.2 → XP_030109035.1  disabled homolog 1 isoform X8

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PHA03247
    Location:254 → 434
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  20. XM_030253182.2 → XP_030109042.1  disabled homolog 1 isoform X15

    Conserved Domains (1) summary
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  21. XM_036163643.1 → XP_036019536.1  disabled homolog 1 isoform X12

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:220 → 401
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  22. XM_036163644.1 → XP_036019537.1  disabled homolog 1 isoform X14

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:220 → 401
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  23. XM_030253180.2 → XP_030109040.1  disabled homolog 1 isoform X15

    Conserved Domains (1) summary
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  24. XM_030253169.2 → XP_030109029.1  disabled homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PHA03247
    Location:287 → 467
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  25. XM_030253177.2 → XP_030109037.1  disabled homolog 1 isoform X10

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  26. XM_006502726.2 → XP_006502789.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502789.1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  27. XM_030253174.1 → XP_030109034.1  disabled homolog 1 isoform X7

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:251 → 432
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  28. XM_030253167.2 → XP_030109027.1  disabled homolog 1 isoform X2

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:286 → 467
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  29. XM_030253173.2 → XP_030109033.1  disabled homolog 1 isoform X6

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  30. XM_030253171.1 → XP_030109031.1  disabled homolog 1 isoform X5

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:253 → 434
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  31. XM_017319950.3 → XP_017175439.1  disabled homolog 1 isoform X8

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PHA03247
    Location:254 → 434
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  32. XM_030253176.2 → XP_030109036.1  disabled homolog 1 isoform X9

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PHA03247
    Location:252 → 432
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  33. XM_030253178.1 → XP_030109038.1  disabled homolog 1 isoform X12

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:220 → 401
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  34. XM_030253179.2 → XP_030109039.1  disabled homolog 1 isoform X13

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:218 → 399
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  35. XM_036163639.1 → XP_036019532.1  disabled homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:288 → 469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25 → 174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

  36. XM_006502735.3 → XP_006502798.1  disabled homolog 1 isoform X11

    UniProtKB/Swiss-Prot
    A2A963, A2A964, A2A965, A2A966, A2A967, A2A970, P97316, P97317, P97318, Q9DAP9
    Conserved Domains (2) summary
    PRK07764
    Location:224 → 405
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl17171
    Location:1 → 110
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97318.2 GenPept UniProtKB/Swiss-Prot:P97318

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