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Dll3 delta like canonical Notch ligand 3 [ Mus musculus (house mouse) ]

Gene ID: 13389, updated on 24-Dec-2024

Summary

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Official Symbol
Dll3provided by MGI
Official Full Name
delta like canonical Notch ligand 3provided by MGI
Primary source
MGI:MGI:1096877
See related
Ensembl:ENSMUSG00000003436 AllianceGenome:MGI:1096877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pu; pudgy
Summary
Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Located in plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E11.5 (RPKM 28.4), whole brain E14.5 (RPKM 11.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Dll3 in Genome Data Viewer
Location:
7 A3; 7 16.67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27992980..28001210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28293555..28301785, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4912 Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene selenoprotein V Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene STARR-positive B cell enhancer ABC_E6527 Neighboring gene predicted gene, 51445 Neighboring gene suppressor of Ty 5, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_18409

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New mutant mouse with skeletal deformities caused by mutation in delta like 3 (Dll3) gene. Shinkai Y, et al. Exp Anim, 2004 Apr. PMID 15153675
  2. Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations. Shapiro F, et al. Biol Open, 2024 Jan 15. PMID 38252118, Free PMC Article
  3. DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis. Noor H, et al. Genomics, 2022 Mar. PMID 35124175
  4. A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development. Hoyne GF, et al. Immunol Cell Biol, 2011 Aug. PMID 21151194
  5. Disordered vertebral and rib morphology in pudgy mice. Structural relationships to human scoliosis. Shapiro F. Adv Anat Embryol Cell Biol, 2016. PMID 27655002

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
    Title: Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
  2. DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis.
    Title: DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis.
  3. Our data showed that activation of Respiratory syncytial virus (RSV) stimulated the differentiation of Th17 in airway microenvironment through activation Notch-1/DLL3, which may be associated with the occurrence and development of RSV-induced asthma.
    Title: Respiratory syncytial virus promoted the differentiation of Th17 cells in airway microenvironment through activation of Notch-1/Delta3.
  4. Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review.
    Title: Disordered vertebral and rib morphology in pudgy mice. Structural relationships to human scoliosis.
  5. Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer.
    Title: The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.
  6. O-fucosylation of DLL3 is required for its function during somitogenesis.
    Title: O-fucosylation of DLL3 is required for its function during somitogenesis.
  7. Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis.
    Title: Mutations in the Notch pathway alter the patterning of multifidus.
  8. Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch.
    Title: A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development.
  9. Dll3 targets Notch1 for lysosomal degradation preventing Notch1 from undergoing post-translational processing.
    Title: Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.
  10. Dll3 are expressed in the developing mouse eye and in retinal progenitor cell.
    Title: Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Radiation induced (1) 
  • Spontaneous (3)  1 citation
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables Notch binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell fate determination NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
delta-like protein 3
Names
M-Delta-3
delta-like 3
delta3
drosophila Delta homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007866.2 → NP_031892.2  delta-like protein 3 precursor

    See identical proteins and their annotated locations for NP_031892.2

    Status: VALIDATED

    Source sequence(s)
    BB868475, BC052002
    Consensus CDS
    CCDS39856.1
    UniProtKB/Swiss-Prot
    O35675, O88516, Q80W06, Q9QWL9, Q9QWZ7
    UniProtKB/TrEMBL
    Q3UND5
    Related
    ENSMUSP00000103951.4, ENSMUST00000108315.4
    Conserved Domains (3) summary
    cd00054
    Location:277 → 308
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:25 → 85
    MNNL; N terminus of Notch ligand
    cl19567
    Location:156 → 246
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27992980..28001210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88516.1 GenPept UniProtKB/Swiss-Prot:O88516

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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