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Dnah8 dynein, axonemal, heavy chain 8 [ Mus musculus (house mouse) ]

Gene ID: 13417, updated on 27-Nov-2024

Summary

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Official Symbol
Dnah8provided by MGI
Official Full Name
dynein, axonemal, heavy chain 8provided by MGI
Primary source
MGI:MGI:107714
See related
Ensembl:ENSMUSG00000033826 AllianceGenome:MGI:107714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPase; Dnahc8; Hst6.7b; P1-Loop
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to be located in axoneme. Predicted to be part of outer dynein arm. Predicted to be active in sperm flagellum. Is expressed in brain and thymus primordium. Used to study spermatogenic failure 46. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 24.8) and thymus adult (RPKM 3.7) See more
Orthologs
human all
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Genomic context

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See Dnah8 in Genome Data Viewer
Location:
17 A3.3; 17 15.71 cM
Exon count:
94
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30845909..31094736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30626935..30875762)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8666 Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene glyoxalase 1 Neighboring gene predicted gene, 24661 Neighboring gene predicted gene, 41561 Neighboring gene STARR-seq mESC enhancer starr_42315 Neighboring gene glucagon-like peptide 1 receptor Neighboring gene predicted gene, 41562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies. Wong SM, et al. Infect Immun, 2023 May 16. PMID 37014212, Free PMC Article
  2. Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. Liu C, et al. Am J Hum Genet, 2020 Aug 6. PMID 32619401, Free PMC Article
  3. Whole-exome sequencing study of hypospadias. Chen Z, et al. iScience, 2023 May 19. PMID 37168556, Free PMC Article
  4. The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini. Samant SA, et al. Dev Biol, 2002 Oct 1. PMID 12297094
  5. [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes]. Sun WP, et al. Fa Yi Xue Za Zhi, 2010 Apr. PMID 20653129

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies.
    Title: Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies.
  2. Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.
    Title: Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.
  3. Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.
    Title: [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].
  4. The interactions of MAP1B with LIS1 in hippocampal neurons, and the association of LIS1 with dynein are reported.
    Title: Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.
  5. major isoform of DNAHC8 is copiously expressed, carries an extended N-terminus and full-length C-terminus, and is stable and equally abundant in both testis and sperm from +/+ and t/t animals
    Title: The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail.
  6. Lis1 does not interact with all dynein complexes found in the brain.
    Title: Regulation of cytoplasmic dynein ATPase by Lis1.
  7. T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini
    Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer dynein arm ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 8
Names
axonemal beta dynein heavy chain 8
axonemal dynein heavy chain 8 Dnahc8
ciliary dynein heavy chain 8
dynein heavy chain 8, axonemal
dynein, axon, heavy chain 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013811.4 → NP_038839.2  dynein axonemal heavy chain 8

    See identical proteins and their annotated locations for NP_038839.2

    Status: VALIDATED

    Source sequence(s)
    AC165951, AC165962, AC166166, AC174471
    Consensus CDS
    CCDS37541.1
    UniProtKB/Swiss-Prot
    E9Q010, O08830, Q3V0D2, Q91V63, Q91XP8, Q91XP9, Q91XQ0, Q99MH8, Q9QY72
    Related
    ENSMUSP00000157469.2, ENSMUST00000236140.2
    Conserved Domains (6) summary
    COG5245
    Location:1358 → 4379
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:382 → 936
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1509 → 1914
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:2049 → 2376
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:3031 → 3293
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4433 → 4728
    Dynein_C; Dynein heavy chain C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    30845909..31094736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160293.1 → XP_036016186.1  dynein axonemal heavy chain 8 isoform X1

    Conserved Domains (4) summary
    COG5245
    Location:1391 → 4412
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:382 → 969
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:2082 → 2409
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4466 → 4761
    Dynein_C; Dynein heavy chain C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XQ0.2 GenPept UniProtKB/Swiss-Prot:Q91XQ0

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