Dr1 down-regulator of transcription 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dr1provided by MGI
Official Full Name: down-regulator of transcription 1provided by MGI
Primary source: MGI:MGI:1100515
See related: Ensembl:ENSMUSG00000029265 AllianceGenome:MGI:1100515
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NC2; Dr1l; NC2beta; 1700121L09Rik
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; histone H3 acetylation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of ATAC complex. Is expressed in central nervous system; early conceptus; genitourinary system; limb mesenchyme; and neural retina. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 18.6), adrenal adult (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 52.82 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108416763..108428387)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108268897..108280521)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice.
Title: The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice.
Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis.
Title: Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis.
Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
Title: Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
part_of negative cofactor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Dr1

Names: NC2-beta; TATA-binding protein-associated phosphoprotein; negative cofactor 2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026106.4 → NP_080382.2 protein Dr1

See identical proteins and their annotated locations for NP_080382.2

Status: PROVISIONAL

Source sequence(s)

AC124107

Consensus CDS

CCDS19509.1

UniProtKB/Swiss-Prot

Q3UT14, Q91WV0

Related

ENSMUSP00000031190.5, ENSMUST00000031190.5

Conserved Domains (1) summary

cl23735
Location:7 → 130

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...