Dtnb dystrobrevin, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtnbprovided by MGI
Official Full Name: dystrobrevin, betaprovided by MGI
Primary source: MGI:MGI:1203728
See related: Ensembl:ENSMUSG00000071454 AllianceGenome:MGI:1203728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in cytoplasm; inhibitory synapse; and nucleus. Is active in GABA-ergic synapse and postsynapse. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 19.5), frontal lobe adult (RPKM 9.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 1.88 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (3622372..3834070)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (3572372..3785486)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
a novel function for dystrobrevin as a motor protein receptor that might play a major role in the transport of components of the dystrophin-associated protein complex to specific sites in the cell
Title: Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.
kinetics of the dystrobrevin-Kif5A interaction showed a lower affinity of alpha compared to that of beta-dystrobrevin for binding to kinesin
Title: Molecular basis of dystrobrevin interaction with kinesin heavy chain: structural determinants of their binding.
AlphaDB, betaDB, & dystrophin are concentrated at a discrete subset of inhibitory synapses on the somata & dendrites of cerebellar Purkinje cells. Sensorimotor behaviors reflecting cerebellar function are perturbed in mice lacking any of these proteins.
Title: Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
biglycan is important for the maintenance of muscle cell integrity and plays a direct role in regulating the expression and sarcolemmal localization of the intracellular signaling proteins dystrobrevin-1 and -2, alpha- and beta1-syntrophin and nNOS
Title: Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-43g4 (e-PCR)
- UniSTS:257802

Dtnb (e-PCR), detects polymorphism
- UniSTS:142876

PMC99916P1 (e-PCR)
- UniSTS:273703

px-16e4 (e-PCR)
- UniSTS:257328

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D6S1904 (e-PCR)
- UniSTS:49754

px-35f1 (e-PCR)
- UniSTS:257640

AU048852 (e-PCR)
- UniSTS:145302

D1S3697 (e-PCR)
- UniSTS:474275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystrobrevin beta

Names: DTN-B; beta-dystrobrevin; mDTN-B; mDTN-BDTN-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162465.3 → NP_001155937.1 dystrobrevin beta isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC155273, CR974568

Consensus CDS

CCDS49015.1

UniProtKB/Swiss-Prot

E9Q0F2, O70563, O70585, Q9CTZ1

UniProtKB/TrEMBL

G3UYM7

Related

ENSMUSP00000126194.3, ENSMUST00000164578.9

Conserved Domains (4) summary

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:16 → 140

EF-hand_2; EF hand

pfam09069
Location:144 → 232

EF-hand_3; EF-hand

cl23720
Location:442 → 522

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001355528.2 → NP_001342457.1 dystrobrevin beta isoform c

Status: VALIDATED

Source sequence(s)

AC155273, CR974568

UniProtKB/TrEMBL

G3UXK0

Related

ENSMUSP00000133722.2, ENSMUST00000173240.8

Conserved Domains (3) summary

COG1196
Location:407 → 497

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
NM_001374710.2 → NP_001361639.1 dystrobrevin beta isoform d

Status: VALIDATED

Source sequence(s)

AC155273, CR974568

Consensus CDS

CCDS88301.1

UniProtKB/TrEMBL

G3UZ87, Q8C8Z9

Related

ENSMUSP00000134392.2, ENSMUST00000173199.8

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
NM_001421902.1 → NP_001408831.1 dystrobrevin beta isoform c

Status: VALIDATED

Source sequence(s)

AC155273, CR974568

UniProtKB/TrEMBL

G3UXK0
NM_007886.3 → NP_031912.2 dystrobrevin beta isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AC155273, AK043436, CR974568

Consensus CDS

CCDS36396.2

UniProtKB/TrEMBL

Q8C8Z9, Q8K0N0

Related

ENSMUSP00000077085.7, ENSMUST00000077930.13

Conserved Domains (4) summary

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

PRK05431
Location:440 → 510

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

RNA

NR_027869.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC155273, CR974568
NR_027870.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC155273, AK043436, CR974568
NR_149729.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155273, CR974568

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

3622372..3834070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314952.3 → XP_017170441.1 dystrobrevin beta isoform X2

UniProtKB/TrEMBL

G3UXK0

Conserved Domains (3) summary

COG1196
Location:407 → 497

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_030246547.2 → XP_030102407.1 dystrobrevin beta isoform X7

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1196
Location:407 → 497

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_017314955.2 → XP_017170444.1 dystrobrevin beta isoform X12

UniProtKB/TrEMBL

G3UXK0

Conserved Domains (3) summary

COG1196
Location:407 → 497

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_017314953.3 → XP_017170442.1 dystrobrevin beta isoform X3

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1340
Location:404 → 485

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_036157176.1 → XP_036013069.1 dystrobrevin beta isoform X10

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1340
Location:404 → 485

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_011243813.4 → XP_011242115.1 dystrobrevin beta isoform X1

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_011243814.4 → XP_011242116.1 dystrobrevin beta isoform X5

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (4) summary

COG1340
Location:434 → 515

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_006514960.5 → XP_006515023.1 dystrobrevin beta isoform X6

UniProtKB/TrEMBL

G3UY34

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_006514961.5 → XP_006515024.1 dystrobrevin beta isoform X8

UniProtKB/TrEMBL

G3UY34

Related

ENSMUSP00000133927.2, ENSMUST00000174547.8

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_006514959.5 → XP_006515022.1 dystrobrevin beta isoform X4

UniProtKB/TrEMBL

Q8C8Z9, Q8K0N0

Related

ENSMUSP00000128230.3, ENSMUST00000164607.9

Conserved Domains (4) summary

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

PRK05431
Location:440 → 510

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_017314954.3 → XP_017170443.1 dystrobrevin beta isoform X9

UniProtKB/TrEMBL

G3UY34

Conserved Domains (4) summary

COG1340
Location:434 → 515

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_030246548.2 → XP_030102408.1 dystrobrevin beta isoform X11

UniProtKB/TrEMBL

G3UY34

Conserved Domains (4) summary

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

PRK05431
Location:440 → 510

PRK05431; seryl-tRNA synthetase; Provisional

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_036157183.1 → XP_036013076.1 dystrobrevin beta isoform X19

Conserved Domains (2) summary

COG1196
Location:157 → 247

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:1 → 39

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
XM_036157182.1 → XP_036013075.1 dystrobrevin beta isoform X19

Conserved Domains (2) summary

COG1196
Location:157 → 247

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:1 → 39

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
XM_030246553.2 → XP_030102413.1 dystrobrevin beta isoform X15

Conserved Domains (4) summary

COG1196
Location:253 → 343

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:87 → 135

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd15901
Location:37 → 60

EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]

cl07621
Location:1 → 60

EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
XM_036157179.1 → XP_036013072.1 dystrobrevin beta isoform X16

Conserved Domains (3) summary

COG1196
Location:253 → 343

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:87 → 135

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09069
Location:1 → 78

EF-hand_3
XM_017314951.3 → XP_017170440.1 dystrobrevin beta isoform X1

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_036157175.1 → XP_036013068.1 dystrobrevin beta isoform X9

UniProtKB/TrEMBL

G3UY34

Conserved Domains (4) summary

COG1340
Location:434 → 515

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

PRK00286
Location:355 → 526

xseA; exodeoxyribonuclease VII large subunit; Reviewed

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_036157181.1 → XP_036013074.1 dystrobrevin beta isoform X18

Conserved Domains (3) summary

COG1340
Location:184 → 265

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

PRK00286
Location:105 → 276

xseA; exodeoxyribonuclease VII large subunit; Reviewed

cl00295
Location:1 → 39

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
XM_030246551.2 → XP_030102411.1 dystrobrevin beta isoform X14

UniProtKB/TrEMBL

G3UYK9

Conserved Domains (4) summary

COG1196
Location:283 → 373

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:87 → 135

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd15901
Location:37 → 60

EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]

cl07621
Location:1 → 60

EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
XM_036157180.1 → XP_036013073.1 dystrobrevin beta isoform X17

Conserved Domains (2) summary

COG1196
Location:187 → 277

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00295
Location:1 → 39

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
XM_030246545.2 → XP_030102405.1 dystrobrevin beta isoform X2

UniProtKB/TrEMBL

G3UXK0

Conserved Domains (3) summary

COG1196
Location:407 → 497

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
XM_030246544.2 → XP_030102404.1 dystrobrevin beta isoform X1

UniProtKB/TrEMBL

Q8C8Z9

Conserved Domains (3) summary

COG1196
Location:437 → 527

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:241 → 289

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16244
Location:54 → 214

EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins