Epx eosinophil peroxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epxprovided by MGI
Official Full Name: eosinophil peroxidaseprovided by MGI
Primary source: MGI:MGI:107569
See related: Ensembl:ENSMUSG00000052234 AllianceGenome:MGI:107569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EPO
Summary: This gene encodes a member of the peroxidase superfamily of enzymes that is produced by eosinophils and plays a critical role in eliminating tissue-invasive parasites. The encoded preproprotein undergoes proteolytic processing to generate a heterodimeric enzyme that forms a predominant component of the intracellular granules of eosinophils. Mice lacking the encoded protein exhibit resistance to ulcerative colitis induced by dextran sulfate. [provided by RefSeq, Jul 2016]
Expression: Biased expression in spleen adult (RPKM 2.1), liver E14 (RPKM 1.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.25 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87754824..87766362, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87863997..87875536, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eosinophil peroxidase contributes to renal fibrosis in the murine unilateral ureteral obstruction model.
Title: Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.
the EPX gene deletion had no impact on eosinophil-mediated clearance of gram-negative Haemophilus influenzae from the airways.
Title: Impact of eosinophil-peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways.
The expression of MBP-1 and EPX was also required for induced lung expression of IL-4/IL-13 in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction.
Title: Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation.
EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma.
Title: Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.
The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event.
Title: Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation.
Title: Eosinophil peroxidase signals via epidermal growth factor-2 to induce cell proliferation.
post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase
Title: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.
Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase.
Title: Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection.
Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice.
Title: Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection.
The activities of EPO, an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma.
Title: Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epx (e-PCR), detects polymorphism
- UniSTS:164920

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eosinophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eosinophil peroxidase

NP_031972.2

EC 1.11.1.7

XP_006532236.1

EC 1.11.1.7

XP_006532237.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430879.1 → NP_001417808.1 eosinophil peroxidase isoform 2

Status: VALIDATED

Source sequence(s)

AL606805

UniProtKB/TrEMBL

Q3V1J3
NM_007946.3 → NP_031972.2 eosinophil peroxidase isoform 1 precursor

See identical proteins and their annotated locations for NP_031972.2

Status: VALIDATED

Source sequence(s)

AL606805

Consensus CDS

CCDS25220.1

UniProtKB/Swiss-Prot

P49290, Q5SW51, Q61798

Related

ENSMUSP00000050497.4, ENSMUST00000049768.4

Conserved Domains (2) summary

cd09824
Location:288 → 700

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

pfam03098
Location:146 → 684

An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87754824..87766362 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532173.4 → XP_006532236.1 eosinophil peroxidase isoform X1

Conserved Domains (1) summary

cd09824
Location:31 → 443

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
XM_006532174.4 → XP_006532237.1 eosinophil peroxidase isoform X2

Conserved Domains (1) summary

cd09824
Location:1 → 387

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases