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Evl Ena-vasodilator stimulated phosphoprotein [ Mus musculus (house mouse) ]

Gene ID: 14026, updated on 18-Sep-2024

Summary

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Official Symbol
Evlprovided by MGI
Official Full Name
Ena-vasodilator stimulated phosphoproteinprovided by MGI
Primary source
MGI:MGI:1194884
See related
Ensembl:ENSMUSG00000021262 AllianceGenome:MGI:1194884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b2600Clo
Summary
Enables SH3 domain binding activity and profilin binding activity. Involved in actin polymerization or depolymerization and positive regulation of actin filament polymerization. Acts upstream of or within cellular response to interferon-gamma. Located in focal adhesion; lamellipodium; and phagocytic vesicle. Is expressed in several structures, including central nervous system; genitourinary system; immune system; retina; and small intestine. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 64.8), CNS E14 (RPKM 64.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Evl in Genome Data Viewer
Location:
12 F1; 12 59.46 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108520942..108654775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108554681..108688516)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene echinoderm microtubule associated protein like 1 Neighboring gene bridging integrator 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33243 Neighboring gene predicted gene, 16596 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109869753-109869906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109873778-109874013 Neighboring gene predicted gene, 53766 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109924618-109924819 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109924858-109925011 Neighboring gene microRNA 342 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109939490-109939738 Neighboring gene predicted gene, 33467 Neighboring gene delta 4-desaturase, sphingolipid 2 Neighboring gene predicted gene, 40572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. Zink J, et al. EMBO Rep, 2021 Feb 3. PMID 33512764, Free PMC Article
  2. Ena/VASP proteins regulate cortical neuronal positioning. Goh KL, et al. Curr Biol, 2002 Apr 2. PMID 11937025
  3. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function. Fedorov AA, et al. Nat Struct Biol, 1999 Jul. PMID 10404224
  4. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Waldman MM, et al. Front Immunol, 2022. PMID 35757762, Free PMC Article
  5. Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. Estin ML, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28320969, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
    Title: EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
  2. EVL selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner.
    Title: Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.
  3. Thus, unlike host proteins characterized in Shigella pathogenesis that promote bacterial spread, VASP and EVL function to limit it.
    Title: Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery.
  4. Altogether these observations demonstrate that ENA/VASP proteins are implicated in the establishment and maintenance of the axonal structure and that a change on their expression levels triggers neuronal degeneration.
    Title: ENA/VASP downregulation triggers cell death by impairing axonal maintenance in hippocampal neurons.
  5. Ena-vasp is required for endothelial barrier function in vivo.
    Title: Ena/VASP is required for endothelial barrier function in vivo.
  6. Ena/VASP proteins regulate cortical neuronal positioning.
    Title: Ena/VASP proteins regulate cortical neuronal positioning.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables profilin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament-based movement NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in actin nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in barbed-end actin filament capping NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ena/VASP-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163394.1 → NP_001156866.1  ena/VASP-like protein isoform 1

    See identical proteins and their annotated locations for NP_001156866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC059810, BC096017
    Consensus CDS
    CCDS49167.1
    UniProtKB/Swiss-Prot
    P70429, Q9ERU8
    UniProtKB/TrEMBL
    Q6PB99
    Related
    ENSMUSP00000021689.7, ENSMUST00000021689.14
    Conserved Domains (2) summary
    cd01207
    Location:5 → 113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:377 → 409
    VASP_tetra; VASP tetramerisation domain

  2. NM_001163395.1 → NP_001156867.1  ena/VASP-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to isoform 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK134563, BC059810
    Consensus CDS
    CCDS49168.1
    UniProtKB/TrEMBL
    F8WJB9, Q6PB99
    Related
    ENSMUSP00000105480.3, ENSMUST00000109854.9
    Conserved Domains (2) summary
    cd01207
    Location:11 → 119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:362 → 394
    VASP_tetra; VASP tetramerisation domain

  3. NM_001163396.2 → NP_001156868.1  ena/VASP-like protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AK134563, AK151633, BC059810
    Consensus CDS
    CCDS49169.1
    UniProtKB/TrEMBL
    E9PVP4, Q6PB99
    Related
    ENSMUSP00000133072.2, ENSMUST00000172409.2
    Conserved Domains (2) summary
    cd01207
    Location:1 → 100
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:364 → 396
    VASP_tetra; VASP tetramerization domain

  4. NM_001422023.1 → NP_001408952.1  ena/VASP-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137155, AC139568, AC152061
    UniProtKB/TrEMBL
    F8WJB9, Q6PB99

  5. NM_007965.3 → NP_031991.3  ena/VASP-like protein isoform 2

    See identical proteins and their annotated locations for NP_031991.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC059810, BC096017
    Consensus CDS
    CCDS26161.1
    UniProtKB/TrEMBL
    Q6PB99
    Related
    ENSMUSP00000076916.6, ENSMUST00000077735.13
    Conserved Domains (2) summary
    cd01207
    Location:5 → 113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:356 → 388
    VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108520942..108654775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515470.3 → XP_006515533.1  ena/VASP-like protein isoform X1

    UniProtKB/TrEMBL
    Q6PB99
    Conserved Domains (2) summary
    cd01207
    Location:11 → 119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:383 → 415
    VASP_tetra; VASP tetramerisation domain

  2. XM_006515471.3 → XP_006515534.1  ena/VASP-like protein isoform X2

    UniProtKB/TrEMBL
    Q6PB99
    Related
    ENSMUSP00000152364.2, ENSMUST00000223109.2
    Conserved Domains (2) summary
    cd01207
    Location:7 → 115
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:379 → 411
    VASP_tetra; VASP tetramerisation domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70429.2 GenPept UniProtKB/Swiss-Prot:P70429

Gene LinkOut

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