mt-nd4l NADH dehydrogenase 4L, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mt-nd4lprovided by ZNC
Official Full Name: NADH dehydrogenase 4L, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011205-11
See related: AllianceGenome:ZFIN:ZDB-GENE-011205-11
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mtnd4l; ND4L
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy and diabetes mellitus. Orthologous to human MT-ND4L (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	MT (non-nuclear)	NC_002333.2 (11009..11305)
105	previous assembly	GRCz10 (GCF_000002035.5)	MT (non-nuclear)	NC_002333.2 (11009..11305)

Chromosome MT - NC_002333.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

fk04f02.x1 (e-PCR)
- UniSTS:200507

fl21g08.x1 (e-PCR)
- UniSTS:202055

fk20d08.y1 (e-PCR)
- UniSTS:200634

fa91b09.x1 (e-PCR)
- UniSTS:189627

fa91b09.x1 (e-PCR)
- UniSTS:189628

fa91b11.x1 (e-PCR)
- UniSTS:189629

fa91b11.x1 (e-PCR)
- UniSTS:189630

fb14f04.x1 (e-PCR)
- UniSTS:190143

fa91e09.x1 (e-PCR)
- UniSTS:189635

fb67d04.x1 (e-PCR)
- UniSTS:190953

fb67d04.x1 (e-PCR)
- UniSTS:190954

Homology

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NADH dehydrogenase subunit 4L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_002333.2 Reference assembly

Range

11009..11305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_059339.1 NADH dehydrogenase subunit 4L (mitochondrion) [Danio rerio]

See identical proteins and their annotated locations for NP_059339.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9MIY2

UniProtKB/TrEMBL

A0A0A0VA51

Conserved Domains (2) summary

MTH00126
Location:1 → 98

ND4L; NADH dehydrogenase subunit 4L; Provisional

MTH00127
Location:67 → 98

ND4; NADH dehydrogenase subunit 4; Provisional