mt-co2 cytochrome c oxidase II, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mt-co2provided by ZNC
Official Full Name: cytochrome c oxidase II, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011205-15
See related: AllianceGenome:ZFIN:ZDB-GENE-011205-15
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mtco2; COX2
Summary: Predicted to enable copper ion binding activity and oxidoreductase activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in ATP synthesis coupled electron transport. Predicted to act upstream of or within electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in brain and muscle. Orthologous to human MTCO2P12 (MT-CO2 pseudogene 12) and MT-CO2 (mitochondrially encoded cytochrome c oxidase II). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	MT (non-nuclear)	NC_002333.2 (8130..8820)
105	previous assembly	GRCz10 (GCF_000002035.5)	MT (non-nuclear)	NC_002333.2 (8130..8820)

Chromosome MT - NC_002333.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 expression.
Title: Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis.
mPGES-1 is developmentally coregulated with COX-2 in vasculature.
Title: Prostaglandin E synthases in zebrafish.

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Pathways from PubChem

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General gene information

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Markers

fk25g03.x1 (e-PCR)
- UniSTS:200706

fa96c09.x1 (e-PCR)
- UniSTS:202604

fb03g10.y1 (e-PCR)
- UniSTS:189845

fk53c11.x1 (e-PCR)
- UniSTS:201142

fb34a11.x1 (e-PCR)
- UniSTS:190419

fb34a11.x1 (e-PCR)
- UniSTS:190420

Homology

Orthologs from OrthoDB

COII

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytochrome-c oxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase subunit II

NP_059334.1

TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_002333.2 Reference assembly

Range

8130..8820

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_059334.1 cytochrome c oxidase subunit II (mitochondrion) [Danio rerio]

See identical proteins and their annotated locations for NP_059334.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9MIY7

UniProtKB/TrEMBL

A0A0A0VG08

Conserved Domains (3) summary

MTH00129
Location:1 → 230

COX2; cytochrome c oxidase subunit II; Provisional

cd13912
Location:93 → 222

CcO_II_C; C-terminal domain of Cytochrome c Oxidase subunit II

pfam02790
Location:2 → 83

COX2_TM; Cytochrome C oxidase subunit II, transmembrane domain