Plxnb3 plexin B3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxnb3provided by MGI
Official Full Name: plexin B3provided by MGI
Primary source: MGI:MGI:2154240
See related: Ensembl:ENSMUSG00000031385 AllianceGenome:MGI:2154240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plxn6
Summary: Enables Rho GDP-dissociation inhibitor binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of GTPase activity; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within nervous system development. Predicted to be located in cell surface. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human PLXNB3 (plexin B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 6.4), cortex adult (RPKM 3.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.4 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72800564..72816116)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73756556..73772510)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that under physiological conditions Plexin-B3 is not essential for the development and function of the central nervous system.
Title: Mice lacking Plexin-B3 display normal CNS morphology and behaviour.
These results help to better comprehend mechanisms used for plexin B3 transcriptional regulation.
Title: Identification and characterization of mouse plexin B3 promoter.
Plexin-B3 is a functional receptor for semaphorin 5A
Title: Plexin-B3 is a functional receptor for semaphorin 5A.
Plexin B3 strongly stimulates neurite outgrowth of primary murine cerebellar neurons.
Title: Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI451018 (e-PCR)
- UniSTS:181298

A008P20 (e-PCR)
- UniSTS:11170

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Rho GDP-dissociation inhibitor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-B3

Names: plexin 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019587.2 → NP_062533.2 plexin-B3 precursor

See identical proteins and their annotated locations for NP_062533.2

Status: VALIDATED

Source sequence(s)

AK140240, AL672094, BX636029

Consensus CDS

CCDS41013.1

UniProtKB/Swiss-Prot

A2AFF9, Q80TH8, Q9QY40

Related

ENSMUSP00000002079.7, ENSMUST00000002079.7

Conserved Domains (9) summary

cd11277
Location:37 → 462

Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3

cd01179
Location:916 → 1001

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:824 → 915

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:464 → 515

PSI; Plexin repeat

pfam01833
Location:1165 → 1232

TIG; IPT/TIG domain

pfam08337
Location:1317 → 1868

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:522 → 608

TIG_plexin; TIG domain

pfam18020
Location:678 → 775

TIG_2; TIG domain found in plexin

cl15674
Location:1004 → 1135

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72800564..72816116

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161810.1 → XP_036017703.1 plexin-B3 isoform X2

Conserved Domains (10) summary

cd11277
Location:37 → 462

Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3

smart00423
Location:622 → 658

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:916 → 1001

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:824 → 915

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:464 → 515

PSI; Plexin repeat

pfam01833
Location:1165 → 1232

TIG; IPT/TIG domain

pfam17960
Location:522 → 608

TIG_plexin; TIG domain

pfam18020
Location:681 → 775

TIG_2; TIG domain found in plexin

cl02569
Location:1317 → 1566

RasGAP; Ras GTPase Activating Domain

cl15674
Location:1004 → 1135

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036161811.1 → XP_036017704.1 plexin-B3 isoform X2

Conserved Domains (10) summary

cd11277
Location:37 → 462

Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3

smart00423
Location:622 → 658

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:916 → 1001

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:824 → 915

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:464 → 515

PSI; Plexin repeat

pfam01833
Location:1165 → 1232

TIG; IPT/TIG domain

pfam17960
Location:522 → 608

TIG_plexin; TIG domain

pfam18020
Location:681 → 775

TIG_2; TIG domain found in plexin

cl02569
Location:1317 → 1566

RasGAP; Ras GTPase Activating Domain

cl15674
Location:1004 → 1135

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036161808.1 → XP_036017701.1 plexin-B3 isoform X1

Conserved Domains (10) summary

cd11277
Location:37 → 462

Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3

smart00423
Location:622 → 658

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:916 → 1001

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:824 → 915

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:464 → 515

PSI; Plexin repeat

pfam01833
Location:1165 → 1232

TIG; IPT/TIG domain

pfam08337
Location:1317 → 1749

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:522 → 608

TIG_plexin; TIG domain

pfam18020
Location:681 → 775

TIG_2; TIG domain found in plexin

cl15674
Location:1004 → 1135

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036161809.1 → XP_036017702.1 plexin-B3 isoform X1

Conserved Domains (10) summary

cd11277
Location:37 → 462

Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3

smart00423
Location:622 → 658

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:916 → 1001

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:824 → 915

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:464 → 515

PSI; Plexin repeat

pfam01833
Location:1165 → 1232

TIG; IPT/TIG domain

pfam08337
Location:1317 → 1749

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:522 → 608

TIG_plexin; TIG domain

pfam18020
Location:681 → 775

TIG_2; TIG domain found in plexin

cl15674
Location:1004 → 1135

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...