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Ankrd6 ankyrin repeat domain 6 [ Mus musculus (house mouse) ]

Gene ID: 140577, updated on 17-Aug-2024

Summary

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Official Symbol
Ankrd6provided by MGI
Official Full Name
ankyrin repeat domain 6provided by MGI
Primary source
MGI:MGI:2154278
See related
Ensembl:ENSMUSG00000040183 AllianceGenome:MGI:2154278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in frontal lobe adult (RPKM 5.9), CNS E14 (RPKM 4.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 14.42 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32804027..32950884, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32804027..32950885, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42267 Neighboring gene LYR motif containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32951659-32951860 Neighboring gene STARR-seq mESC enhancer starr_09871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32993701-32993916 Neighboring gene enoyl-CoA hydratase domain-containing protein 2, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_09876 Neighboring gene STARR-seq mESC enhancer starr_09877 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069120-33069321 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069732-33069841 Neighboring gene STARR-seq mESC enhancer starr_09878 Neighboring gene STARR-seq mESC enhancer starr_09880 Neighboring gene Ras-related GTP binding D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain. Ikeda M, et al. Stem Cells, 2010 Nov. PMID 20827749
  2. Centrosomal localization of Diversin and its relevance to Wnt signaling. Itoh K, et al. J Cell Sci, 2009 Oct 15. PMID 19789178, Free PMC Article
  3. Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Tissir F, et al. Dev Dyn, 2002 Aug. PMID 12203740
  4. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Haribaskar R, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19591803
  5. New aspects of Wnt signaling pathways in higher vertebrates. Huelsken J, et al. Curr Opin Genet Dev, 2001 Oct. PMID 11532397

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation.
    Title: Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.
  2. Results indicate that Diversin plays an important role in the proliferation of neuroblasts in the subventricular zone of the adult brain.
    Title: Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain.
  3. These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling.
    Title: Centrosomal localization of Diversin and its relevance to Wnt signaling.
  4. These data suggest that ankyrin repeat domain 6 (Ankrd6) may be involved in brain development in interaction not only with Celsr/Flamingo but also with other signaling pathways.
    Title: Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 6
Names
diversin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012450.1 → NP_001012453.1  ankyrin repeat domain-containing protein 6

    See identical proteins and their annotated locations for NP_001012453.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript represents variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AV290829, BC065177, CF531081
    Consensus CDS
    CCDS18018.1
    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Related
    ENSMUSP00000041300.5, ENSMUST00000035719.11
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  2. NM_001012451.1 → NP_001012454.1  ankyrin repeat domain-containing protein 6

    See identical proteins and their annotated locations for NP_001012454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AV290829, BC065177, CF533090
    Consensus CDS
    CCDS18018.1
    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Related
    ENSMUSP00000081802.2, ENSMUST00000084750.8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  3. NM_001355587.1 → NP_001342516.1  ankyrin repeat domain-containing protein 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AV290829, BC065177, CJ057243
    Consensus CDS
    CCDS18018.1
    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  4. NM_080471.3 → NP_536719.2  ankyrin repeat domain-containing protein 6

    See identical proteins and their annotated locations for NP_536719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AV290829, BC065177, CF531081
    Consensus CDS
    CCDS18018.1
    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Related
    ENSMUSP00000081801.2, ENSMUST00000084749.8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32804027..32950884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163674.1 → XP_036019567.1  ankyrin repeat domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (2) summary
    PHA03095
    Location:19 → 232
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:107 → 138
    ANK; ANK repeat [structural motif]

  2. XM_036163672.1 → XP_036019565.1  ankyrin repeat domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (2) summary
    PHA03095
    Location:19 → 232
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:107 → 138
    ANK; ANK repeat [structural motif]

  3. XM_036163673.1 → XP_036019566.1  ankyrin repeat domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (2) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]

  4. XM_036163675.1 → XP_036019568.1  ankyrin repeat domain-containing protein 6 isoform X5

    Conserved Domains (2) summary
    sd00045
    Location:18 → 48
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:22 → 114
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_011249919.4 → XP_011248221.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248221.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  6. XM_011249921.4 → XP_011248223.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248223.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  7. XM_011249920.4 → XP_011248222.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248222.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  8. XM_011249924.4 → XP_011248226.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248226.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  9. XM_011249922.4 → XP_011248224.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248224.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)

  10. XM_011249923.4 → XP_011248225.1  ankyrin repeat domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011248225.1

    UniProtKB/Swiss-Prot
    A2ANZ0, Q69ZU8, Q6P1A8, Q8VHD9
    UniProtKB/TrEMBL
    A2ANY8
    Conserved Domains (3) summary
    PHA03095
    Location:29 → 265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]
    pfam11179
    Location:520 → 643
    DUF2967; Protein of unknown function (DUF2967)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZU8.2 GenPept UniProtKB/Swiss-Prot:Q69ZU8

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