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NEK7 NIMA related kinase 7 [ Homo sapiens (human) ]

Gene ID: 140609, updated on 10-Dec-2024

Summary

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Official Symbol
NEK7provided by HGNC
Official Full Name
NIMA related kinase 7provided by HGNC
Primary source
HGNC:HGNC:13386
See related
Ensembl:ENSG00000151414 MIM:606848; AllianceGenome:HGNC:13386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues See more
Orthologs
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Genomic context

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See NEK7 in Genome Data Viewer
Location:
1q31.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (198156998..198322420)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (197416379..197581805)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198126128..198291550)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197887073-197887799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197890605-197891127 Neighboring gene chromosome 1 open reading frame 53 Neighboring gene LIM homeobox 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:198001212-198001386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198025825-198026449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2284 Neighboring gene proline rich 13 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4677 Neighboring gene VISTA enhancer hs1322 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198283627-198284283 Neighboring gene NANOG hESC enhancer GRCh37_chr1:198392710-198393375 Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Wang P, et al. Cell Death Dis, 2019 Jun 3. PMID 31160567, Free PMC Article
  2. NEK7 is required for G1 progression and procentriole formation. Gupta A, et al. Mol Biol Cell, 2017 Jul 15. PMID 28539406, Free PMC Article
  3. NEK7 is a centrosomal kinase critical for microtubule nucleation. Kim S, et al. Biochem Biophys Res Commun, 2007 Aug 17. PMID 17586473
  4. Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo. Zhou L, et al. Oncotarget, 2016 Apr 5. PMID 26921196, Free PMC Article
  5. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Byrne MJ, et al. Biochem J, 2020 Apr 30. PMID 32242624, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
    Title: P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
  2. ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
    Title: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
  3. The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
    Title: The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
  4. Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.
    Title: Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.
  5. Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1beta release in NK/T-cell lymphoma.
    Title: Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1β release in NK/T-cell lymphoma.
  6. Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease.
    Title: Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease.
  7. EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
    Title: EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
  8. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
    Title: Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
  9. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
    Title: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
  10. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-kappaB signaling.
    Title: NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to potassium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in spindle assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek7
Names
NIMA (never in mitosis gene a)-related kinase 7
never in mitosis A-related kinase 7
nimA-related protein kinase 7
NP_598001.1
XP_011507511.1
XP_016855833.1
XP_016855834.1
XP_016855835.1
XP_016855836.1
XP_047302516.1
XP_047302517.1
XP_047302518.1
XP_047302519.1
XP_047302520.1
XP_047302521.1
XP_047302523.1
XP_047302524.1
XP_047302525.1
XP_047302526.1
XP_047302528.1
XP_054190469.1
XP_054190470.1
XP_054190471.1
XP_054190472.1
XP_054190473.1
XP_054190474.1
XP_054190475.1
XP_054190476.1
XP_054190477.1
XP_054190478.1
XP_054190479.1
XP_054190480.1
XP_054190481.1
XP_054190482.1
XP_054190483.1
XP_054190484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133494.3 → NP_598001.1  serine/threonine-protein kinase Nek7

    See identical proteins and their annotated locations for NP_598001.1

    Status: VALIDATED

    Source sequence(s)
    AC093419, AK313411, DB498485
    Consensus CDS
    CCDS1394.1
    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8
    Related
    ENSP00000356355.4, ENST00000367385.9
    Conserved Domains (1) summary
    cd08224
    Location:33 → 294
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    198156998..198322420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446560.1 → XP_047302516.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  2. XM_047446563.1 → XP_047302519.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8

  3. XM_047446572.1 → XP_047302528.1  serine/threonine-protein kinase Nek7 isoform X7

  4. XM_017000345.2 → XP_016855834.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  5. XM_047446562.1 → XP_047302518.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8

  6. XM_047446567.1 → XP_047302523.1  serine/threonine-protein kinase Nek7 isoform X4

    UniProtKB/TrEMBL
    B2R8K8

  7. XM_047446570.1 → XP_047302526.1  serine/threonine-protein kinase Nek7 isoform X7

  8. XM_017000344.2 → XP_016855833.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  9. XM_017000346.2 → XP_016855835.1  serine/threonine-protein kinase Nek7 isoform X3

    UniProtKB/TrEMBL
    B2R8K8

  10. XM_047446565.1 → XP_047302521.1  serine/threonine-protein kinase Nek7 isoform X4

    UniProtKB/TrEMBL
    B2R8K8

  11. XM_011509209.2 → XP_011507511.1  serine/threonine-protein kinase Nek7 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:9 → 158
    PKc_like; Protein Kinases, catalytic domain

  12. XM_047446569.1 → XP_047302525.1  serine/threonine-protein kinase Nek7 isoform X6

  13. XM_017000347.2 → XP_016855836.1  serine/threonine-protein kinase Nek7 isoform X5

  14. XM_047446568.1 → XP_047302524.1  serine/threonine-protein kinase Nek7 isoform X6

  15. XM_047446561.1 → XP_047302517.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  16. XM_047446564.1 → XP_047302520.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    197416379..197581805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334495.1 → XP_054190470.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  2. XM_054334498.1 → XP_054190473.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8

  3. XM_054334503.1 → XP_054190478.1  serine/threonine-protein kinase Nek7 isoform X4

    UniProtKB/TrEMBL
    B2R8K8

  4. XM_054334508.1 → XP_054190483.1  serine/threonine-protein kinase Nek7 isoform X7

  5. XM_054334494.1 → XP_054190469.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  6. XM_054334501.1 → XP_054190476.1  serine/threonine-protein kinase Nek7 isoform X3

    UniProtKB/TrEMBL
    B2R8K8

  7. XM_054334502.1 → XP_054190477.1  serine/threonine-protein kinase Nek7 isoform X4

    UniProtKB/TrEMBL
    B2R8K8

  8. XM_054334507.1 → XP_054190482.1  serine/threonine-protein kinase Nek7 isoform X7

  9. XM_054334506.1 → XP_054190481.1  serine/threonine-protein kinase Nek7 isoform X6

  10. XM_054334504.1 → XP_054190479.1  serine/threonine-protein kinase Nek7 isoform X5

  11. XM_054334505.1 → XP_054190480.1  serine/threonine-protein kinase Nek7 isoform X6

  12. XM_054334496.1 → XP_054190471.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  13. XM_054334499.1 → XP_054190474.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8

  14. XM_054334509.1 → XP_054190484.1  serine/threonine-protein kinase Nek7 isoform X7

  15. XM_054334497.1 → XP_054190472.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/TrEMBL
    B2R8K8

  16. XM_054334500.1 → XP_054190475.1  serine/threonine-protein kinase Nek7 isoform X2

    UniProtKB/Swiss-Prot
    A6NGT8, Q8TDX7
    UniProtKB/TrEMBL
    B2R8K8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDX7.1 GenPept UniProtKB/Swiss-Prot:Q8TDX7

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