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fads2 fatty acid desaturase 2 [ Danio rerio (zebrafish) ]

Gene ID: 140615, updated on 2-Nov-2024

Summary

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Official Symbol
fads2provided by ZNC
Official Full Name
fatty acid desaturase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-011212-1
See related
Ensembl:ENSDARG00000019532 AllianceGenome:ZFIN:ZDB-GENE-011212-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Fadsd6; DRD5/D6; wu:fb64c04; wu:fb69e08; zgc:112502
Summary
Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within liver development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alar plate midbrain region; fat cell; nervous system; optic vesicle; and pleuroperitoneal region. Orthologous to several human genes including FADS2 (fatty acid desaturase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fads2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (4133489..4148719, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (4007830..4023060, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene EPS8 signaling adaptor L2 Neighboring gene uncharacterized LOC137489317 Neighboring gene uncharacterized LOC137489318 Neighboring gene leucine rich repeat containing 10B Neighboring gene stabilizer of axonemal microtubules 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species. Monroig O, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Aug. PMID 21571087
  2. Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Ashikawa Y, et al. Heliyon, 2017 Mar. PMID 28367511, Free PMC Article
  3. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases. Watanabe K, et al. J Lipid Res, 2016 Jan. PMID 26590171, Free PMC Article
  4. Partial fads2 Gene Knockout Diverts LC-PUFA Biosynthesis via an Alternative Δ8 Pathway with an Impact on the Reproduction of Female Zebrafish (Danio rerio). Bláhová Z, et al. Genes (Basel), 2022 Apr 15. PMID 35456508, Free PMC Article
  5. Transcriptional activation of zebrafish fads2 promoter and its transient transgene expression in yolk syncytial layer of zebrafish embryos. Tay SS, et al. Sci Rep, 2018 Mar 1. PMID 29497119, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
    Title: Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
  2. these results implicate that Z-FADS, the sole fatty acid desaturase ever been identified in zebrafish, can serve as a universal fatty acid desaturase during lipogenesis.
    Title: Identification of the proteins required for fatty acid desaturation in zebrafish (Danio rerio).
  3. desaturase displayed significant upregulation in expression during the oocyte maturation stage.
    Title: Upregulated mRNA expression of desaturase and elongase, two enzymes involved in highly unsaturated fatty acids biosynthesis pathways during follicle maturation in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyl-CoA delta5-desaturase activity IEA
Inferred from Electronic Annotation
more info
  
enables linoleoyl-CoA desaturase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acyl-CoA 6-desaturase
Names
D5D/D6D fatty acid desaturase
delta(5)/Delta(6) fatty acid desaturase
delta-6 fatty acyl desaturase
NP_571720.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131645.2 → NP_571720.2  acyl-CoA 6-desaturase

    See identical proteins and their annotated locations for NP_571720.2

    Status: PROVISIONAL

    Source sequence(s)
    BC049438
    UniProtKB/Swiss-Prot
    Q7ZWF3, Q9DEX7
    Related
    ENSDARP00000022396.6, ENSDART00000023278.7
    Conserved Domains (3) summary
    PLN03199
    Location:21 → 439
    PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
    cd03506
    Location:162 → 412
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
    pfam00173
    Location:21 → 94
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    4133489..4148719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DEX7.1 GenPept UniProtKB/Swiss-Prot:Q9DEX7

Gene LinkOut

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