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Wdr5 WD repeat domain 5 [ Mus musculus (house mouse) ]

Gene ID: 140858, updated on 5-Jan-2025

Summary

Official Symbol
Wdr5provided by MGI
Official Full Name
WD repeat domain 5provided by MGI
Primary source
MGI:MGI:2155884
See related
Ensembl:ENSMUSG00000026917 AllianceGenome:MGI:2155884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Big; Big-3; 2410008O07Rik
Summary
Enables histone H3K4 methyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within peptidyl-lysine methylation; positive regulation of gluconeogenesis; and skeletal system development. Located in nucleus. Part of ATAC complex. Is expressed in several structures, including cerebral cortex; colon; genitourinary system; hemolymphoid system gland; and vault of skull. Orthologous to human WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.0), limb E14.5 (RPKM 18.7) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr5 in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27405159..27426547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27515147..27536535)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene predicted gene, 54108 Neighboring gene STARR-seq mESC enhancer starr_04005 Neighboring gene STARR-seq mESC enhancer starr_04007 Neighboring gene STARR-positive B cell enhancer mm9_chr2:27395293-27395594 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27395737-27395846 Neighboring gene STARR-seq mESC enhancer starr_04008 Neighboring gene predicted gene, 25541 Neighboring gene predicted gene 13421

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-lysine methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within skeletal system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
 
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
 
part_of Set1C/COMPASS complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of histone methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 5
Names
BMP2-induced 3-kb gene protein
WD repeat-containing protein BIG-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080848.2NP_543124.1  WD repeat-containing protein 5

    See identical proteins and their annotated locations for NP_543124.1

    Status: VALIDATED

    Source sequence(s)
    AA023626, AF416510
    Consensus CDS
    CCDS15829.1
    UniProtKB/Swiss-Prot
    P61965, Q922C9
    UniProtKB/TrEMBL
    Q3UNQ3
    Related
    ENSMUSP00000109585.4, ENSMUST00000113952.10
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27405159..27426547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497672.4XP_006497735.1  WD repeat-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006497735.1

    UniProtKB/Swiss-Prot
    P61965, Q922C9
    UniProtKB/TrEMBL
    Q3UNQ3
    Conserved Domains (2) summary
    cd00200
    Location:37331
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4885
    7WD40; WD40 repeat [structural motif]